Recruiting · registry status

Testing magnetic stimulation aimed at deep sleep

Researchers investigate whether changing deep-sleep activity with magnetic stimulation affects the course of Parkinson’s.

Testing a treatment or activity · Study reference: NCT06002581

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date): 2023-09-03
Main measurements finished (planned): 2026-07-28
Study finished (planned): 2026-07-28

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 50 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1. Meet the clinically definite or clinically probable PD according to the MDS 2015 version. 2. Chinese Han population (three generations), age greater than or equal to 50 years old, less than or equal to 80 years old, male or female. 3. Hoehn-Yahr stages 1-4. 4. The dose of levodopa drug therapy was stable three weeks before enrollment and during the follow-up period. 5. Right-handed. 6. The patient signed a written informed consent. Exclusion Criteria: 1. Any form of Parkinsonism other than primary PD. 2. Those who have received neurosurgical intervention or stereotaxic brain surgery for PD, or have previously received TMS treatment. 3. Cognitive dysfunction (MMSE ≤ 24 points) or those who cannot cooperate with the scale score. 4. Persons with mental disabilities. 5. Pregnant women. 6. There are contraindications for rTMS treatment. 7. There are contraindications for MRI examination. 8. Baseline PSG suggests other sleep disorders such as moderate to severe OSAS; BMI\>=30. 9. Patients who are addicted to alcohol, taking SSRIs, TCAs, sedative hypnotics, histamine antagonists and other drugs and food that may affect NREM and REM sleep structure. 10. Those who are unwilling to participate in the study or unable to sign the informed consent form; and other circumstances that the researcher considers inappropriate to participate in the study. \-

Full study name & original research details

Official study title

Clinical Study on the Efficacy and Safety of rTMS Regulating Slow-wave Sleep to Delay the Progression of Parkinson's Disease

Short title used by the registry

Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease

Original description

At present, no drug therapy has been proven to delay the progression of Parkinson's disease (PD). rTMS, as a non-invasive neuromodulation method, can regulate Slow-wave sleep (SWS). SWS is recognized closely related to neurodegeneration. However, there has been no clinical studies on if rTMS could delay the progression of PD by regulating SWS. The main purpose of this study is to explore the changes of SWS in non-rapid eye movement (NREM) sleep period in PD patients by using rTMS, and the relationship with potential improvements of SWS and motor symptom delay. The study aims to find a potential new treatment strategy to delay the neurodegenerative process in PD patients by modulating SWS by rTMS.

Conditions reported: Parkinson's Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT06002581 ↗ — RECRUITING; checked 2026-10-13

Study type: Interventional
Interventions: rTMS real stimulation stage1; rTMS shame stimulation stage1; rTMS real stimulation stage 2
Phases: NA
Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Start date reported by registry: 2023-09-03 (actual)

Registry updated: 2025-12-09 · Status last verified by the registry submitter: 2025-12

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Xiaoying Zhu, doctor · +86 21 63240090 · docxiaoying@163.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

Recruiting

Xiaoying Zhu, MD · +86 13817659260 · docxiaoying@163.com

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.