Recruiting · registry status

Testing stimulation of two brain areas for thinking problems

Researchers study the safety and tolerability of stimulating two brain regions in people with Parkinson’s and mild thinking difficulties.

Testing a treatment or activity · Study reference: NCT05968703

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date): 2025-04-08
Main measurements finished (planned): 2027-01-31
Study finished (planned): 2027-07-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 21 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Diagnosis of Parkinson's disease (PD) * Approved (or planning on) for subthalamic nucleus (STN) deep brain stimulation (DBS) * Willingness to withdraw from clinical medication regimen when necessary for research visits * Ability to provide informed consent Exclusion Criteria: * Dementia * Unstable medical, psychiatric conditions including significant untreated depression, history of suicidal attempt, or current suicide ideation * History of seizures * Pregnant * Requires MRI * Unable to walk 100 feet without an assistive device

Full study name & original research details

Official study title

Neurostimulation of the Nucleus Basalis of Meynert for the Cognitive-Motor Syndrome in Parkinson's Disease

Short title used by the registry

Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease

Original description

The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor symptoms in individuals with Parkinson's disease. The main question it aims to answer is: Is a combined deep brain stimulation approach targeting the STN and NBM with four DBS leads safe and tolerable for cognitive and cognitive-motor symptoms in individuals with Parkinson's disease with Mild Cognitive Impairment. Ten participants are anticipated to be enrolled. Participants will undergo a modification of the traditional STN DBS approach for motor symptoms of PD. In addition to the two leads placed within the STN, two additional leads will be placed with the NBM for treatment of cognitive and cognitive-motor symptoms. Novel stimulation patterns will be used within the NBM to target cognitive and cognitive-motor symptoms using an investigational software. Participants will be followed over two years while receiving this therapy with assessments at baseline and every six months. Assessments will include a combination of neuropsychological evaluations, cognitive assessments, motor tasks (including gait/walking), and questionnaires to evaluate the treatment. Two different surgical trajectories will be used, with half the cohort randomized to each group. This will allow comparison of the impact of surgical trajectory on the intervention.

Conditions reported: Parkinson's Disease; Mild Cognitive Impairment

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT05968703 ↗ — RECRUITING; checked 2026-10-13

Study type: Interventional
Interventions: Combined STN+NBM DBS
Phases: NA
Sponsor: Helen M. Bronte-Stewart
Start date reported by registry: 2025-04-08 (actual)

Registry updated: 2025-05-30 · Status last verified by the registry submitter: 2025-05

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Study Coordinator · 650-723-6709 · bronte-stewart-lab@stanford.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Stanford Neuroscience Health Center

Stanford, California, United States

Recruiting

Study Coordinator · 650-723-6709 · bronte-stewart-lab@stanford.edu

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.