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Using feedback about brain activity during movement training

Researchers investigate brain activity during imagined movement and feedback-based training aimed at walking and balance in Parkinson’s.

Testing a treatment or activity · Study reference: NCT05800470

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported actual date)
2025-03-19
Main measurements finished (planned)
2025-08-01
Study finished (planned)
2025-08-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 40 years to 85 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Part 1 Additional Inclusion Criteria for PD: 1. diagnosis of idiopathic PD by neurologist with Hoehn and Yahr stage \< 4; 2. stable medical condition; 3. capability of walking independently without walking devices. Exclusion Criteria: 1. cognitive impairment indicated by MMSE score \< 24; 2. motor imagery ability indicated by KVIQ score \< 25; 3. unable recognize 26 letters in the English alphabet 4. history of diseases or conditions known to interfere with participating this study (e.g. epilepsy, metal implants in the brain, or deep brain stimulation); 5. diagnosis of any other neurological disease or psychiatric disorder (e.g. stroke, anxiety disorder, or depression); 6. using central nervous system medications other than for PD, e.g. antiepileptic drugs in recent 3 months. Part 2 Inclusion Criteria: 1. aged 40-85 y/o; 2. diagnosis of idiopathic PD by neurologist with Hoehn and Yahr stage \< 4; 3. stable medical condition; 4. capability of walking independently for 10 minutes, which is the time needed for imagery walking training in order to eliminate the possible influence of physical fatigue. Exclusion Criteria: 1. cognitive impairment indicated by MMSE score \< 24; 2. history of diseases or conditions known to interfere with participating this study (e.g. epilepsy, metal implants in the brain, or deep brain stimulation); 3. diagnosis of any other neurological disease or psychiatric disorder (e.g. stroke, anxiety disorder, or depression); 4. using central nervous system medications other than for PD, e.g. antiepileptic drugs in recent 3 months.
Full study name & original research details

Official study title

The Novel Application of fNIRS-based Neurofeedback to Enhance Effects of Motor Imagery on Balance and Gait Performance in Individuals With Parkinson's Disease

Short title used by the registry

The Effects of fNIRS-based Neurofeedback Training on Balance and Gait in Parkinson's Disease

Original description

A cross-sectional study (part 1) aims to investigate the influence of fatigue on the MI ability in PD compared to healthy controls. A randomized controlled trial (part 2) aims to compare the effect of fNIRS-based NFB-MI on balance and gait performance versus MI only in people with PD.

Further description from the registry

To fulfill out study purposes, a cross-sectional study (Part I) and an interventional randomized controlled trial (Part II) are designed. In Part I, people with PD and the age-matched healthy controls will be recruited and perform imagery and actual walking tasks. The level of general fatigue will be measured by Traditional Chinese version of Multidimensional Fatigue Inventory (MFI-TC) in people with PD. The level of concurrent fatigue will be induced by 30-minute cognitive tasks consisting of A-X continuous performance test, 2 back and mental rotation test and will be assessed by Brunel Mood Scale (BRUMS-C) in people with PD. Independent t test will be used to compare the MI ability between PD group and healthy control group. The Pearson's correlation coefficient will be used to examine the relationships between general fatigue level (MFI) and MI ability and between concurrent fatigue level (BRUMS) and MI ability in people with PD. In Part II, people with PD will be randomly allocated to either NFB-MI, MI or MT group. Every participant will receive 12 sessions of training in four weeks. NFB-MI and MI training will consist of 20-min MI with or without neurofeedback respectively followed by 20-min of balance and gait training. In the MT group, participants will receive 40-min of balance and gait training. Outcome measures, including Mini Balance Evaluation Systems Test (Mini-BEST), Timed up-and-go test (TUG), gait performance, will be assessed at pre-, post-test, and follow-up. MI ability and fatigue will be assessed at pre-, mid-and post-test. A two-way analysis of variance (ANOVA) with repeated measure will be used to determine the time by group interaction for all the outcomes. Post hoc test with Bonferroni correction will be applied for significant interaction. Significant level for part I and part II will be set at p \< 0.05.

Conditions reported: Parkinson Disease; Movement Disorder, Functional

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
fNIRS-based neurofeedback with motor imagery; Kinesthetic motor imagery; Motor training
Phases
NA
Sponsor
National Yang Ming Chiao Tung University
Start date reported by registry
2025-03-19 (actual)

Registry updated: 2025-08-07 · Status last verified by the registry submitter: 2025-08

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Ray-Yau Wang · +88628267210 · rywang@nycu.edu.tw

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

National Yang Ming Chiao Tung University

Taipei, None Selected, Taiwan

Recruiting

Ray-Yau Wang, Ph.D · 88628267210 · rywang@nycu.edu.tw

Ray-Yau Wang, Ph.D

Facility not reported

Taiwan

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.