RESEARCH / PARTICIPATIONBack to the library
← Find a study
Recruiting · registry status

Using speech to track changes in Parkinson’s

Researchers study whether computer analysis of speech can detect changes in movement, emotions and thinking in Parkinson’s.

Testing a treatment or activity · Study reference: NCT05765110

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

Follow this study

Looking for volunteers

Start (reported actual date)
2023-01-03
Main measurements finished (planned)
2026-12-31
Study finished (planned)
2026-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 30 years to 75 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Patients with Parkinson's Disease Inclusion Criteria: * Written informed consent * Idiopathic PD according to the Movement Disorders Society Criteria; * Age of participants \> 30 and ≤ 75 years; * Treatment with or without bilateral deep brain stimulation in the subthalamic nucleus; * Fluent in German or French Exclusion Criteria: * Dysarthria caused in addition by a condition other than PD (e.g. stroke, myasthenia); * Clinical diagnosis of aphasia; * Brain disease other than Parkinson's disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.). * Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points); * Depression with acute suicidal ideation Healthy Controls Inclusion Criteria: * Written informed consent * Adults from 50-70 years old; * Fluent in German or French Exclusion Criteria: * Diagnosis of Parkinson's disease; * Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points); * Suffering from brain disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.); * Clinical diagnosis of aphasia, dysarthria, and stuttering; * Suffering from or diagnosed with psychiatric illnesses according to DSM-V criteria
Full study name & original research details

Official study title

SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease

Original description

With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.

Further description from the registry

Parkinson's disease (PD) affects mobility (motor function), thought processes (cognition) and mood (emotion). The language is one of the most complex programs in humans. It contains information about mobility, thinking and mood at the same time. These three levels of agility, thinking and mood are subject to spontaneous fluctuations and can be influenced by external stimuli such as pictures that induce emotions. In addition, these three levels are influenced on the one hand by Parkinson's disease itself, and on the other hand by its treatment with medication or with deep brain stimulation (DBS). For this reason, the investigators would like to investigate language in Parkinson's disease patients in a very detailed computerized way for motor, cognitive and emotional elements for better management of therapies. With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect fluctuations in motor, mood, and thinking in Parkinson's disease patients. Even in healthy subjects, speech changes in a situational manner, due to which the investigators will also include healthy subjects as a control group.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Dopaminergic OFF drug state; DBS OFF state; Dopaminergic ON drug state; DBS ON state
Phases
NA
Sponsor
Insel Gruppe AG, University Hospital Bern
Start date reported by registry
2023-01-03 (actual)

Registry updated: 2026-05-22 · Status last verified by the registry submitter: 2026-05

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Paul Krack, Prof. · 31 66 4 03 71 · paul.krack@insel.ch

Mario Sousa, MD · 31 664 23 49 · mario.sousa@insel.ch

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Czech Technical University Prague

Prague, Czechia

In progress; recruitment closed

University Hospital Inselspital, Berne

Bern, Switzerland

Recruiting

Paul Krack, Prof. · 31 66 4 03 71 · paul.krack@insel.ch

Mario Sousa, MD · 31 664 23 49 · mario.sousa@insel.ch

Facility not reported

Czechia

Status not reported

Facility not reported

Switzerland

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.