Recruiting · registry status

Testing a supplement containing bacteria and fibre

Researchers investigate the safety and possible effects of a probiotic and prebiotic fibre combination alongside usual Parkinson’s treatment.

Testing a treatment or activity · Study reference: NCT05576818

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

Open the official registry record ↗

Follow this study

Looking for volunteers

Start (reported actual date): 2022-06-30
Main measurements finished (planned): 2025-06
Study finished (planned): 2025-06

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

Ramadan ME, Mostafa TM, Ghali AA, El-Afify DR. Randomized controlled trial evaluating synbiotic supplementation as an adjuvant therapy in the treatment of Parkinson's disease. Inflammopharmacology. 2025 Jul;33(7):3897-3908. doi: 10.1007/s10787-025-01752-8. Epub 2025 May 28. ↗
Registry derived research reference

Who can join?

Ages 45 years to 65 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Age between 45 and 65 years old * Both sexes * Patients with Parkinson's disease on dopamine replacement therapy * Modified Hoehn and Yahr stage, MHY 1-4 Exclusion Criteria: * Patients who are currently using or used antibiotics therapy in the preceding month * Patients who are currently using or used other probiotic products in the preceding two weeks * Patients scheduled to undergo GIT surgery or those underwent GIT surgery * Patients with Known allergy to probiotics * Patients receiving artificial enteral or intravenous nutrition * Patients with depression and/or psychosis * Patients taking antioxidant and/or anti-inflammatory medications * Patients with Hyperthyroidism * Patients with inflammatory condition and/or condition involving oxidative stress * Smokers * Modified Hoehn \& Yahr stage MHY 5

Full study name & original research details

Official study title

Clinical Study Evaluating the Efficacy and Safety of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease

Short title used by the registry

Effect of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease

Original description

This study aims to investigate the possible efficacy and safety of synbiotic preparation of Lactobacillus acidophilus probiotic with prebiotic fibers as an adjuvant therapy in the treatment of Parkinson's disease

Conditions reported: Parkinson's Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT05576818 ↗ — RECRUITING; checked 2026-10-13

Study type: Interventional
Interventions: Lactobacillus acidophilus 10 billion colony forming unit (CFU) and prebiotic fibers
Phases: PHASE3
Sponsor: Tanta University
Start date reported by registry: 2022-06-30 (actual)

Registry updated: 2025-04-10 · Status last verified by the registry submitter: 2025-04

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Mohamed E Ramadan · 201205280849 · mohamed_ehab@pharm.tanta.edu.eg

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Tanta University

Tanta, El Gharbia, Egypt

Recruiting

Mohamed E Ramadan · 201205280849 · mohamed_ehab@pharm.tanta.edu.eg

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.