Recruiting · registry status

Following Parkinson’s over time in Luxembourg

Researchers collect health assessments, biological samples, genetic information and digital measurements to understand Parkinson’s and support earlier detection and better treatment research.

Learning by observing or collecting information · Study reference: NCT05266872

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

Who can join?

Age 18 years and over · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Subjects with neurodegenerative disease or having Parkinson's disease (typical PD or atypical parkinsonism) * Subjects of all genders with a full capacity of consent * Subjects with a limited consent capacity if the legal guardian/authorised representative is in agreement * Subjects of at least 18 years of age at the time of inclusion Exclusion Criteria: * Refusal to sign the informed consent * Limited capacity of consent on the part of the donor, if there is no legally determined guardian/authorised representative, or the latter is not present or does not agree with the inclusion * Active cancer * Pregnant women * Underage subjects of less than 18 years of age * Refusal to comply with mandatory sample collection * For invasive procedures, i.e., lumbar puncture and skin biopsy: relevant blood clotting impairment, e.g., anamnestic evidence of frequent or prolonged bleedings.

Full study name & original research details

Official study title

Biomaterial Collection for Neurodegenerative Disease Research (ND Collection)

Short title used by the registry

Earlier Diagnosis and Better Treatment Mission Related to the Cohort Programme

Original description

The Luxembourg Parkinson's Study is an ongoing longitudinal nationwide monocentric observational study. It collects extensive clinical, molecular, genetic, and digital device-based longitudinal data, as well as foreseen post-mortem diagnostic validation (Hipp et al., 2018). The cohort consists of more than 1,600 participants from Luxembourg and the Greater Region, comprising patients with typical PD or atypical parkinsonism - irrespective of disease stage, age, cognitive status, comorbidities, or linguistic background - followed-up annually and age- and sex-matched healthy control subjects followed-up every 4 years. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, the investigators have implemented an open-source digital platform that has been partly harmonized with other international PD cohort studies. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies (including blood, urine, stool, saliva, hair, skin biopsy and cerebrospinal fluid). All data and samples are stored, curated, and integrated into state-of-the-art data and biobank facilities.

Conditions reported: Parkinson Disease

Study type: Observational
Interventions: Observational study with sample and data collection
Phases: Not reported
Sponsor: Luxembourg Institute of Health
Start date reported by registry: 2014-12-19 (actual)

Registry updated: 2026-09-14 · Status last verified by the registry submitter: 2026-09

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Rejko KRÜGER, Dr · +352 44 11 4848 · rejko.krueger@uni.lu

Parkinson clinic · +352 44 11 4848 · parkinson@chl.lu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Centre Hospitalier de Luxembourg (CHL), "Parkinson's Research Clinic"

Luxembourg, Luxembourg

Recruiting

Rejko KRÜGER · +35244114848 · rejko.krueger@uni.lu

Clinical and Epidemiological Investigation Center (CIEC)

Luxembourg, Luxembourg

Recruiting

Manon Gantenbein · +352 26970-807 · Manon.Gantenbein@lih.lu

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.