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Completed · registry status

Study To Assess Adverse Events and Change in Disease Activity Of 24-hour Continuous Subcutaneous Infusion Of ABBV-951 In Adult Participants With Advanced Parkinson's Disease

A plain-language introduction is being prepared for this study. Open it to read the original description, who can join and how to contact the team.

Testing a treatment or activity · Study reference: NCT04750226

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Open the official registry record ↗

Follow this study

Completed; watching for results

Start (reported actual date)
2021-02-18
Main measurements finished (reported actual date)
2026-04-27
Study finished (reported actual date)
2026-04-27

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — completed

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

Real-World Safety and Effectiveness of 24-Hour Foslevodopa/Foscarbidopa in Parkinson's Disease: ROSSINI Study 6-Month Interim Results.
This paper mentions the study ID; the relationship needs review · 2026

Soileau M, Kumar R, Parab A, Brion T, White K, Yan CH, Shah MB, Kukreja P, Facheris MF, Shewale A, Aldred J. Patients' experience with and perspectives on long-term use of continuous subcutaneous infusion of foslevodopa/foscarbidopa in Parkinson's disease. J Neurol. 2025 May 22;272(6):416. doi: 10.1007/s00415-025-13123-y. ↗
Registry derived research reference

Participation rules recorded for this study

Age 30 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: \- Completion of the parent study, Study M15-736 or Study M20-339. Exclusion Criteria: \- Participant considered by the investigator to be an unsuitable candidate to receive ABBV-951 for any reason.
Full study name & original research details

Official study title

An Open-Label Extension of Studies M15-736 and M20-339 to Evaluate the Safety and Tolerability of 24-Hour Daily Exposure of ABBV-951 in Subjects With Advanced Parkinson's Disease

Short title used by the registry

Study To Assess Adverse Events and Change in Disease Activity Of 24-hour Continuous Subcutaneous Infusion Of ABBV-951 In Adult Participants With Advanced Parkinson's Disease

Original description

Parkinson's disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person. Some symptoms of PD are tremors, stiffness, and slowness of movement. This study will assess how safe and effective ABBV-951 is in adult participants with PD. Adverse events and change in disease activity is evaluated. ABBV-951 is an investigational (unapproved) drug containing Levodopa Phosphate/Carbidopa Phosphate (LDP/CDP) given as an infusion under the skin for the treatment of Parkinson's Disease. Adult participants with advanced PD and who have completed M15-736 or M20-339 study will be enrolled. Approximately 130 participants will be enrolled in the study in approximately 60 sites in the United States and Australia. Participants will receive continuous subcutaneous infusion (CSCI) (under the skin) of ABBV-951 for 96 weeks during the Primary Treatment Period and during the optional Extended Treatment Period. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the course of the study at a hospital or clinic. The effect of the treatment will be checked by medical and remote telephone assessments, blood tests, checking for side effects, and completing questionnaires.

Conditions reported: Parkinson's Disease (PD)

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
ABBV-951
Phases
PHASE3
Sponsor
AbbVie
Start date reported by registry
2021-02-18 (actual)

Registry updated: 2026-06-01 · Status last verified by the registry submitter: 2026-05

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

No central contact is listed. Check the location contacts or the official registry record.

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

University of Alabama at Birmingham - Main /ID# 217814

Birmingham, Alabama, United States

Status not reported

Usa Mitchell Cancer Institute /ID# 218467

Mobile, Alabama, United States

Status not reported

Xenoscience, Inc /ID# 222515

Phoenix, Arizona, United States

Status not reported

Muhammad Ali Parkinson Center /ID# 218609

Phoenix, Arizona, United States

Status not reported

Movement Disorders Center of Arizona /ID# 218471

Scottsdale, Arizona, United States

Status not reported

Neuro Pain Research Center /ID# 217720

Fresno, California, United States

Status not reported

Loma Linda University Medical /ID# 217724

Loma Linda, California, United States

Status not reported

University of California, Los Angeles /ID# 218460

Los Angeles, California, United States

Status not reported

SC3 Research Group - Pasadena /ID# 223018

Pasadena, California, United States

Status not reported

University of California, San /ID# 218595

San Diego, California, United States

Status not reported

Duplicate_Cedars-Sinai Medical Center-West Hollywood /ID# 218607

West Hollywood, California, United States

Status not reported

University of Colorado Hospital /ID# 218486

Aurora, Colorado, United States

Status not reported

Alpine Clinical Research Center /ID# 218461

Boulder, Colorado, United States

Status not reported

Denver Neurological Research, LLC /ID# 217811

Denver, Colorado, United States

Status not reported

CenExel Rocky Mountain Clinical Research, LLC /ID# 217731

Englewood, Colorado, United States

Status not reported

Georgetown University Hospital /ID# 218599

Washington D.C., District of Columbia, United States

Status not reported

Visionary Investigators Network - Miami /ID# 217726

Miami, Florida, United States

Status not reported

Renstar Medical Research /ID# 217837

Ocala, Florida, United States

Status not reported

Neurology Associates Ormond Beach /ID# 217800

Ormond Beach, Florida, United States

Status not reported

Parkinson's Disease Treatment Center of Southwest Florida /ID# 222679

Port Charlotte, Florida, United States

Status not reported

University of South Florida- Neuroscience Institute /ID# 218481

Tampa, Florida, United States

Status not reported

Premiere Research Institute - Palm Beach /ID# 218743

West Palm Beach, Florida, United States

Status not reported

Rush University Medical Center /ID# 217807

Chicago, Illinois, United States

Status not reported

University of Chicago Medical Center /ID# 218611

Chicago, Illinois, United States

Status not reported

St Elizabeth's Medical Center - Brighton /ID# 223082

Brighton, Massachusetts, United States

Status not reported

St. Lukes Hosp. of Kansas City /ID# 218604

Kansas City, Missouri, United States

Status not reported

Washington University-School of Medicine /ID# 217723

St Louis, Missouri, United States

Status not reported

Global Neurosciences Institute /ID# 218472

Lawrenceville, New Jersey, United States

Status not reported

Northwell Health /ID# 218600

Lake Success, New York, United States

Status not reported

M3 Wake Research - Raleigh /ID# 218482

Raleigh, North Carolina, United States

Status not reported

The Orthopedic Foundation /ID# 218608

New Albany, Ohio, United States

Status not reported

The Movement Disorder Clinic of Oklahoma /ID# 218580

Tulsa, Oklahoma, United States

Status not reported

Legacy Medical Group - Neurology /ID# 217804

Portland, Oregon, United States

Status not reported

University of Pennsylvania /ID# 218605

Philadelphia, Pennsylvania, United States

Status not reported

Thomas Jefferson University Hospital /ID# 218594

Philadelphia, Pennsylvania, United States

Status not reported

Prisma Health-Upstate /ID# 217803

Greenville, South Carolina, United States

Status not reported

Coastal Neurology /ID# 222893

Port Royal, South Carolina, United States

Status not reported

KCA Neurology - Franklin /ID# 222811

Franklin, Tennessee, United States

Status not reported

Vanderbilt University Medical Center /ID# 217722

Nashville, Tennessee, United States

Status not reported

St. David's Healthcare Partnership, L.P., LLP /ID# 248148

Austin, Texas, United States

Status not reported

Houston Pulmonary Sleep and Allergy Associates /ID# 218473

Cypress, Texas, United States

Status not reported

Texas Movement Disorder Specialists /ID# 218610

Georgetown, Texas, United States

Status not reported

Baylor College of Medicine /ID# 217728

Houston, Texas, United States

Status not reported

University of Utah Health Care /ID# 218597

Salt Lake City, Utah, United States

Status not reported

Neurological Associates - Forest Ave /ID# 218458

Richmond, Virginia, United States

Status not reported

Inland Northwest Research /ID# 222520

Spokane, Washington, United States

Status not reported

Duplicate_Medical College of Wisconsin /ID# 217721

Milwaukee, Wisconsin, United States

Status not reported

Liverpool Hospital /ID# 221693

Liverpool, New South Wales, Australia

Status not reported

Westmead Hospital /ID# 218418

Westmead, New South Wales, Australia

Status not reported

Gold coast University Hospital /ID# 221694

Southport, Queensland, Australia

Status not reported

Royal Adelaide Hospital /ID# 218417

Adelaide, South Australia, Australia

Status not reported

The Royal Melbourne Hospital /ID# 218419

Parkville, Victoria, Australia

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.