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Looking for early signs of Parkinson’s in people at higher risk

Researchers screen people at increased risk for changes involving alpha-synuclein, a protein linked to Parkinson’s, before typical movement symptoms develop.

Learning by observing or collecting information · Study reference: NCT04724941

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

Open the official registry record ↗

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Looking for volunteers

Start (reported actual date)
2021-06-01
Main measurements finished (planned)
2027-12
Study finished (planned)
2027-12

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 50 years to 99 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Age between 50 and 99 Exclusion Criteria: * Presence of clinical PD at the time of study inclusion * Other significant neurologic diseases affecting the central nervous system (e.g. Multiple sclerosis) * other significant diseases e.g. orthopaedic diseases affecting quantitative motor assessment * in case of participation in the lumbal puncture substudy: contraindications for the performance of lumbal puncture (bleeding tendency, intake of anticoagulants)
Full study name & original research details

Official study title

Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study

Original description

The PASS-PD study is set out to screen individuals from the general population with an increased risk for the development of Parkinson's Disease (PD) and to investigate this highly enriched cohort longitudinally for five year. A special focus is placed on implementation of ethical standards for early risk disclosure in PD.

Further description from the registry

The PASS-PP Study is designed to combine the latest developments in clinical and biomarker research to 1. understand the distribution of risk profiles for PD in the general population, especially regarding non-motor symptoms 2. identify subjects with a likelihood of developing PD 3. follow individuals with a high likelihood/risk to develop PD in the future (compared to individuals with low risk and) in a prospective study 4. understand the potential of biological markers to increase prediction of progression/conversion 5. identify subtypes of PD patients, by providing a detailed clinical phenotyping with a main focus on non-motor symptoms cluster 6. provide a framework of ethical handling of early risk disclosure in PD

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
No intervention
Phases
Not reported
Sponsor
University Hospital Schleswig-Holstein
Start date reported by registry
2021-06-01 (actual)

Registry updated: 2025-09-22 · Status last verified by the registry submitter: 2025-09

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Eva Schaeffer, Dr. · 004943150023983 · eva.schaeffer@uksh.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Department for Neurology, University of Kiel

Kiel, Germany

Recruiting

Eva Schäffer, Dr. · 004943150023983 · eva.schaeffer@uksh.de

Facility not reported

Germany

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.