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Understanding brain activity linked to thinking difficulties

Researchers record activity in connected brain areas to learn about thinking difficulties in Parkinson’s.

Testing a treatment or activity · Study reference: NCT04715984

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

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Looking for volunteers

Start (reported actual date)
2021-06-02
Main measurements finished (planned)
2029-08
Study finished (planned)
2029-08

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 40 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion criteria: * Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center * Planned clinical electrode trajectory that contacts caudate * Age greater than or equal to 40 * Diagnosis of Parkinson's disease * Able to participate in intraoperative testing * English speaking Exclusion criteria: * Age less than 40 * Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions) * Movement disorder other than Parkinson's disease
Full study name & original research details

Official study title

Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment

Short title used by the registry

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Original description

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Neurophysiology recordings; Neural stimulation
Phases
NA
Sponsor
Vanderbilt University Medical Center
Start date reported by registry
2021-06-02 (actual)

Registry updated: 2026-06-12 · Status last verified by the registry submitter: 2026-01

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Lucas Chang, BA · 615-421-3046 · lucas.m.chang@vumc.org

Sarah Bick, MD · 615-343-9822 · Sarah.Bick@vumc.org

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Recruiting

Lucas Chang, BA · 615-421-3046 · lucas.m.chang@vumc.org

Sarah Bick, MD

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.