Recruiting · registry status

Testing stimulation for thinking control and mood

Researchers study whether stimulation of the cerebellum, a part of the brain, affects thinking and mood across several neurological and mental-health conditions.

Testing a treatment or activity · Study reference: NCT03217110

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported actual date): 2017-11-30
Main measurements finished (planned): 2028-12-01
Study finished (planned): 2028-12-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 years to 90 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * A clinical diagnosis consistent with enrollment Exclusion Criteria: * History of recurrent seizures or epilepsy * Any other neurological or psychiatric diagnosis outside the diagnosis for which the participant is enrolled. * Active substance use disorder in the past 6 months other than tobacco use disorder. * Inability to consent for study. * Pacemaker * Coronary Stent * Defibrillator * Neurostimulation * Claustrophobia * Uncontrolled high blood pressure * Atrial fibrillation * Significant heart disease * Hemodynamic instability * Kidney disease * Pregnant, trying to become pregnant, or breast feeding

Full study name & original research details

Official study title

Cerebellar Transcranial Magnetic Stimulation and Cognitive Control

Short title used by the registry

Cerebellar Stimulation and Cognitive Control

Original description

The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

Further description from the registry

Our recent work found that patients with Parkinson's disease and schizophrenia have impaired frontal EEG rhythms in the theta and delta range (1-8 Hz).We have been using transcranial direct current stimulation to recover these rhythms as patients perform elementary cognitive tasks. We found that although we are able to modulate cerebellar and frontal activity with tDCS, this effect is minimal as the depth of the current is not great enough to modulate all cerebellar activity. Here we use transcranial magnetic stimulation (TMS) to modulate neural activity in the frontal cortex and recover cognitive function in patients with autism, schizophrenia, bipolar disorder and Parkinson's disease. The purpose of the study is to explore cerebellar stimulation as a potential new treatment to restore frontal activity and cognitive function in autism, schizophrenia, bipolar disorder and Parkinson's disease.Subjects will be brought in for 5 to 6 separate visits, with cerebellar or sham TMS stimulation twice per day for 5 days, as well as 3 follow-up visits.During these visits the patient will have cognitive, disease-specific and emotional testing, including EEG testing and MRI imaging. For those participants that received sham stimulation we will again use EEG to record how single pulses of magnetic or electrical stimulation influences other regions of the cerebellum and downstream brain regions. These data will provide insight into how the cerebellum may influence downstream brain regions and play a role in cognitive and motor performance. All data will be analyzed offline to determine if performance on the interval timing task and/or frontal brain rhythms change following transcranial magnetic stimulation as compared to the pre-stimulation blocks of trials. Additionally, we will analyze changes in their cognitive function, symptom ratings, functional and structural MRI, and mood following stimulation. Controls will receive both active and sham treatment for comparison.

Conditions reported: Schizophrenia; Autism Spectrum Disorder; Bipolar Disorder; Depression; Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT03217110 ↗ — RECRUITING; checked 2026-10-11
ClinicalTrials.gov · NCT03217110 ↗ — Recruiting; WHO ICTRP processed 2026-03-30; checked 2026-10-11

Study type: Interventional
Interventions: Repetitive Transcranial Magnetic Stimulation (rTMS); Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Phases: NA
Sponsor: Krystal Parker, PhD
Start date reported by registry: 2017-11-30 (actual)

Registry updated: 2026-03-19 · Status last verified by the registry submitter: 2026-03

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Krystal L Parker, Ph.D · 319-353-4554 · CT201610712@gmail.com

Benjamin Pace, M.S. · 319-384-9302 · benjamin-pace@uiowa.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

University of Iowa

Iowa City, Iowa, United States

Recruiting

Krystal L Parker, Ph.D · 319-353-3554 · krystal-parker@uiowa.edu

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.