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Understanding a brain area involved in starting movement

Researchers study how a deep brain area helps control movement and how changes there relate to difficulty moving in Parkinson’s.

Testing a treatment or activity · Study reference: NCT01682668

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date)
2013-02
Main measurements finished (planned)
2026-07
Study finished (planned)
2026-08

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 years to 70 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion criteria for patients who will be operated 1. Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank) 2. Age between 18 and 70; 3. Motor complications in the form of fluctuations in motor state or dyskinesias induced by dopaminergic therapy, despite medical treatment optimum; 4. Other medical conditions that are stable or do not interfere with the procedure proposed; 5. Excellent responsiveness to levodopa (UPDRS motor score improvement greater than 50% in the acute levodopa test) 6. Brain MRI without abnormality 7. Normality of biological examinations 8. Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent) 9. Patient with social health insurance Criteria for non-inclusion of Parkinsonian patients who will be operated 1. Contraindication to examinations necessary for inclusion 2. Evolutionary psychiatric pathology; 3. Dementia(MMS\<24/30); 4. Patients with a medical condition that makes surgery dangerous neuro-surgical; 5. Bleeding-promoting diseases and laboratory test abnormalities clotting; 6. Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia). 7. Taking drugs interfering with coagulation for 1 month before intervention. 8. Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty Selection criteria for non-operated patients 1. Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank); 2. Age between 18 and 70; 3. Other medical conditions that are stable or do not interfere with the proposed protocol; 4. Presence of axial signs (gait and/or balance disorders) no improved by antiparkinsonian treatment 5. Brain MRI without notable abnormality 6. Normality of biological examinations 7. Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent) 8. Patient with social health insurance Criteria for non-inclusion of non-operated patients 1. Contraindication to examinations necessary for inclusion 2. Progressive psychiatric pathology; 3. Dementia (MMS\<24/30); 4. Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia). 5. Persons under guardianship, curatorship or any other administrative or judicial measuredeprivation of rights and liberty Inclusion criteria for group 3 patients (already operated) 1. Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank); 2. Bilateral deep brain stimulation of the subthalamic nucleus for more than 1 year 3. Age between 18 and 70; 4. Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent) 5. Patient with social health insurance Criteria for non-inclusion of Parkinsonian patients (already operated) 1. Contraindication to examinations necessary for inclusion 2. Evolutionary psychiatric pathology; 3. Dementia(MMS\<24/30); 4. Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty Inclusion criteria for healthy subjects 1. Age between 18 and 70 years old 2. Normal neurological examination 3. Person who voluntarily and informedly agreed to participate in the study (signature of a written consent) 4. Patient with social health insurance Criteria for non-inclusion of healthy subjects 1. Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights and freedom 2. Existence of neurological, orthopedic or psychiatric history 3. Existence of contraindications to MRI (cardiac or neural pacemaker, ferromagnetic surgical clips, implants and metallic objects, foreign bodies intraocular, pregnancy, claustrophobia).
Full study name & original research details

Official study title

Role of the Subthalamic Nucleus in the Control of Movement: Physiopathology of Akinesia in Parkinson's Disease.

Short title used by the registry

Subthalamic Nucleus, Akinesia and Parkinson's Disease

Original description

This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN stimulation improves motor signs in PD patients .

Conditions reported: Parkinson's Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Bilateral subthalamic stimulation
Phases
NA
Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Start date reported by registry
2013-02 (actual)

Registry updated: 2026-07-07 · Status last verified by the registry submitter: 2026-07

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Marie-Laure Welter, MD, PhD · marielaure.welter@icm-institute.org

Carine Karachi, MD, PhD · carine.karachi@gmail.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Groupe Hospitalier Pitie-Salpêtrière

Paris, PARIS, France

Recruiting

Marie-Laure Welter, MD, PhD · marie-laure.welter@psl.aphp.fr

CIC-GHPS

Paris, France

Recruiting

Marie-Laure WELTER, PH · 0142162461 · marielaure.welter@icm-institute.org

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.