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Anaesthesia and inflammation

This study compares anaesthetic approaches and measures inflammatory responses in people with Parkinson's.

Testing a treatment or activity · Study reference: KCT0004410

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported date)
2018-06-10

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 40(year) to 75(year) · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: both

Inclusion criteria: Patients with Parkinson's disease aged 40-75 years who underwent cerebral stimulator implantation to control symptoms under general anesthesia Exclusion criteria: patients without signing consent, patients with myocardial infarction or coronary artery disease aside from diabetes and hypertension heart disease, patients with lung disease such as asthma or chronic obstructive pulmonary disease (COPD), patients with AST / ALT greater than normal, patient with a medical history or a history of hypersensitivity to inhalation anesthetics or propofol
Full study name & original research details

Official study title

Effect of inhalational anesthetics and total intravenous anesthesia on inflammatory cytokine after surgery in patients with Parkinson’s disease

Short title used by the registry

Effect of anesthetic method on inflammatory response in Parkinson' disease

Original description

Intervention: Drug : Patients in the inhalation anesthesia group induce anesthesia by tracheal intubation 1-2 minutes after propofol 1-2 mg / kg and rocuronium 0.6-1 mg / kg IV administration. Thereafter, anesthesia is maintained at 1-2 vol.% Sevoflurane, 0.01-0.2 kg / kg / min remifentanil, and O 2 / air (FiO 2 0.4). In total intravenous anesthesia(TIVA) group, propofol 3-6 µg / ml, remifentanil 2-6 ng / ml, rocuronium 0.6-1 mg / kg using TCI (target controlled infusion) are administered for anesthesia induction. After tracheal intubation, anesthesia is maintained with propofol 2-4 µg / ml, remifentanil 2-4 ng / ml, O2 / air (FiO2 0.4). Primary outcome: perioperative serum IL-17 level Secondary outcome: perioperative serum IL-1?, TNF-?

Conditions reported: ;Diseases of the nervous system

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Drug : Patients in the inhalation anesthesia group induce anesthesia by tracheal intubation 1-2 minutes after propofol 1-2 mg / kg and rocuronium 0.6-1 mg / kg IV administration. Thereafter, anesthesia is maintained at 1-2 vol.% Sevoflurane, 0.01-0.2 kg / kg / min remifentanil, and O 2 / air (FiO 2 0.4). In total intravenous anesthesia(TIVA) group, propofol 3-6 µg / ml, remifentanil 2-6 ng / ml, rocuronium 0.6-1 mg / kg using TCI (target controlled infusion) are administered for anesthesia induction. After tracheal intubation, anesthesia is maintained with propofol 2-4 µg / ml, remifentanil 2-4 ng / ml, O2 / air (FiO2 0.4).
Phases
Phase4
Sponsor
The Catholic University of Korea, Seoul St. Mary's Hospital
Start date reported by registry
2018-06-10 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Jin Joo · +82-2-2258-6162 · jiyo1004@hanmail.net

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Korea, Republic of

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.