Recruiting · registry status

Blood flow in the brain when standing

Researchers are studying changes in brain blood flow when blood pressure falls on standing.

Testing a treatment or activity · Study reference: JPRN-UMIN000056074

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Results reported

Start (reported date): 2024-11-10
Study finished (reported date): 2026-03-31

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Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 18years-old and over · Ask the team who can join

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Sex eligibility reported by registry: male and female

Inclusion criteria: Patients with neurological diseases that may cause autonomic neuropathy Examples: Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, multiple system atrophy, corticobasal degeneration, progressive supranuclear palsy, spinocerebellar degeneration, familial amyloid polyneuropathy, autoimmune autonomic ganglionopathy, diabetic neuropathy, Sjogren's syndrome, paraneoplastic neurologic syndromes, autoimmune central nervous system inflammatory disease, vasculitis syndrome Exclusion criteria: Pregnant or at risk of pregnancy. Patients with stroke or with a history of stroke. Patients with neuroendocrine tumor. Patients who are not able to cross their legs, push, hold a standing position, and walk. Patients who are judged by the investigator to be inappropriate to participate in this study.

Full study name & original research details

Official study title

CLOVER - Cerebral Low Oxygen and Vascular Evaluation in Relapse (indicating orthostatic events or syncope) - Investigation of cerebral blood flow changes in patients with orthostatic hypotension

Short title used by the registry

Investigation of cerebral blood flow changes in patients with orthostatic hypotension

Original description

Intervention: Cerebral blood flow is measured by near-infrared spectroscopy using HOT-2000 manufactured by NeU. Primary outcome: concentration of oxygenated hemoglobin Secondary outcome: Serum BDNF, serum GFAP, serum UCH-L1, serum NfL, MMSE, FAB

Conditions reported: Patients with neurological disorders that may cause autonomic neuropathy Examples: Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, multiple system atrophy, corticobasal ganglia degeneration, progressive supranuclear palsy, spinocerebellar degeneration, familial amyloid polyneuropathy, autoimmune autonomic ganglionopathy, diabetic neuropathy, Sjogren's syndrome, paraneoplastic neurologic syndromes, autoimmune CNS inflammatory diseases, vasculitis syndromes

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

JPRN · JPRN-UMIN000056074 ↗ — Recruiting; WHO ICTRP processed 2026-06-29; checked 2026-10-11

Study type: Interventional
Interventions: Cerebral blood flow is measured by near-infrared spectroscopy using HOT-2000 manufactured by NeU.
Phases: Not selected
Sponsor: Hamamatsu University School of Medicine
Start date reported by registry: 2024-11-10 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Akiyuki Takenouchi · 053-435-2111 · takenouchi@hama-med.ac.jp

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Japan

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.