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How vagus nerve stimulation affects the brain

Researchers are investigating brain responses to stimulation of a nerve involved in communication between the brain and body.

Testing a treatment or activity · Study reference: JPRN-UMIN000051488

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Results reported

Start (reported date)
2023-05-01
Study finished (reported date)
2027-01-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

Read the results reported in the registry

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18years-old to 65years-old · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: male and female

Inclusion criteria: Epileptic patients. Normal adults. For normal adults, patients between the ages of 18-65 years with no diagnosed congenital or developmental disorders. Patients with refractory epilepsy who will undergo intracranial electrode placement to identify the epileptic focal area. Patients with Parkinson's disease, dystonia, essential tremor, stroke-induced movement disorder, stroke aftereffects, or involuntary movement disorder who are undergoing deep brain stimulation therapy to relieve symptoms of the above diseases. Exclusion criteria: Exclusion criteria for patients and healthy adults undergoing functional magnetic resonance imaging testing 1. people who have a pacemaker implanted in their body. 2. people who have metal in their body for surgery or drug injection. 3. people who may have accidentally received a piece of metal in their body from working in the metal processing industry, etc. 4. people who are claustrophobic. 5. People who experience severe shortness of breath when lying down.
Full study name & original research details

Official study title

Elucidation of the neurophysiological mechanisms of vagus nerve stimulation - Elucidating the Mechanisms of vagus nerve stimulation

Short title used by the registry

Elucidation of the neurophysiological mechanisms of vagus nerve stimulation

Original description

Intervention: Presentation of taVNS (up to 1 day in healthy adults and epilepsy group, up to 5 days in patients with implanted electrodes) Primary outcome: Differences in brain activity (BOLD signal intensity in cortical and subcortical regions) at rest and during cognitive tasks during taVNS stimulation will be compared between epileptic patients and healthy controls. Secondary outcome: Brain activity (BOLD signal intensity and local potentials) at rest and during cognitive task loading were compared before and during taVNS stimulation using functional timing image resonance and local potential measurements. The results of behavioral indices of cognitive tasks are compared before and during taVNS stimulation.

Conditions reported: Epilepsy, Parkinson's disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Presentation of taVNS (up to 1 day in healthy adults and epilepsy group, up to 5 days in patients with implanted electrodes)
Phases
Not applicable
Sponsor
Jichi Medical University
Start date reported by registry
2023-05-01 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Kensuke Kawai · 0285-58-7373 · kenkawai-tky@jichi.ac.jp

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Japan

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.