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Inosine and the onset of medicine wearing off

This study tests whether inosine changes when wearing-off periods begin in early Parkinson's.

Testing a treatment or activity · Study reference: JPRN-UMIN000020527

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date)
2016-02-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 20years-old and over · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: male and female

Inclusion criteria: Diagnosed as having Parkinson's disease according to UK Parkinson's Disease Society Brain Bank criteria. Within 5 years (60 months) from the start of any anti-Parkinsonism medication. 19 item-Wearing-off questionnaire <= 1 at the time of the screening visit and Visit 1. Serum urate level <= 5.5 mg/dL in male or <= 4.2 mg/dL in female. Age >=20 and obtained written informed consent. Exclusion criteria: A history of kidney stones, gout(or chronic arthritis), ischemic heart disease A history of kidney failure of eGFR <= 60 at the screening visit. Having uncontrolled hypertension which is defined as SBP>=160 or DBP >=100 Current treatment with medication which slows urate excretion, which is defined as taking diuretics, losartan, anti-tuberculosis drugs or immune-suppression agents. Being pregnant or having an intention to become pregnant during the study period. Other factors that investigators deem inappropriate to enroll for the trial. (e.g. Having malignancy, arthritis which is difficult to discern from gout, severe allergic history to drugs)
Full study name & original research details

Official study title

Multi-centered, placebo-controlled, double-blind, randomized clinical trial to assess the effect of oral inosine on the onset of wearing off in patients with early stage Parkinson's disease - Randomized clinical trial to assess the disease modifying effect of oral inosine for patients with Parkinson's disease

Short title used by the registry

Multi-centered, placebo-controlled, double-blind, randomized clinical trial to assess the effect of oral inosine on the onset of wearing off in patients with early stage Parkinson's disease

Original description

Intervention: Inosine to maintain a serum urate level between 6.0-7.5 mg/dL for 2 years Lactose as a placebo for 2 years Primary outcome: Time between the first administration of the drug to the onset of wearing off (19 item-Wearing-off questionnaire > 2) Secondary outcome: Time taken to reach Hoehn&Yahr 3.0 or above Score change in UPDRS Medication of levodopa over 300 Change in SBR in DATSCAN Change in H/M in MIBG

Conditions reported: Parkinson's disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Inosine to maintain a serum urate level between 6.0-7.5 mg/dL for 2 years Lactose as a placebo for 2 years
Phases
Phase II
Sponsor
Ehime University Graduate School of Medicine
Start date reported by registry
2016-02-01 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Hirotaka Iwaki · 089-960-5095 · h-iwaki@m.ehime-u.ac.jp

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Japan

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.