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Following brain proteins and changes in memory

Researchers are using repeated specialised scans to study protein build-up and the progression of dementia.

Learning by observing or collecting information · Study reference: JPRN-UMIN000017978

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date)
2015-06-03

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 20years-old and over · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: male and female

Inclusion criteria: Both the disease severity and treatment is not considered for the criteria. With respect to subjects with hypertension, hyperglycemia, and hyperlipidemia, overlapping disease is approved. Exclusion criteria: The subject who have already took part in the previous examination in the study of dementia using [11C]PBB3 PET imaging in a year is excluded.
Full study name & original research details

Official study title

Comprehensive and longitudinal study for neurodegenerative dementia using [11C]PBB3 positron emission tomography - Comprehensive and longitudinal study for dementia using [11C]PBB3 positron emission tomography

Short title used by the registry

Comprehensive and longitudinal study for neurodegenerative dementia using [11C]PBB3 positron emission tomography

Original description

Primary outcome: The association of the changes observed in amyloid imaging ([11C]PIB-PET) and tau imaging ([11C]PBB3-PET) with their clinical progression of the disease such as their cognitive decline. Secondary outcome: The contribution of risk factor such as hypertension, hyperglycemia (diabetes), and hyperlipidemia to the cerebral amyloid/tau load or the pathophysiology of the dementia.

Conditions reported: The dementia includes mild cognitive impairment, Alzheimer's disease, frontemporal degeneration, Lewy body disease, Parkinson's disease with dementia, corticobasal degeneration, progressive supranuclear palsy. Morever, subjects with hypertension, hyperglycemia (diabetes), and hyperlipidemia, which associate with dementia, are also included.

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Not reported
Phases
Not selected
Sponsor
National Institute of Radiological Sciences
Start date reported by registry
2015-06-03 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Hitoshi Shimada · 043-206-3251 · shimada@nirs.go.jp

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Japan

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.