A traditional medicine formula alongside Parkinson's treatment

Inclusion criteria: The general inclusion criteria were: 1. 20-80 years old; 2. taking stable medications within the past month; PD patients were included in the study if they also met the following criteria: 1. both met the above diagnostic criteria of traditional Chinese and western medicine; 2. According to TCM syndrome differentiation it belongs to the sea of marrow deficiency type; 3. Evaluation of patients with revised Hoehn-Yahr stage 1-3; 4. Dopamine replacement and other drugs were taken stably for more than 1 month; 5. voluntarily participated in the study and signed the informed consent; 6. those with correct understanding of the significance of this study and good compliance. Exclusion criteria: 1. Parkinsonism or Parkinsonism plus syndrome caused by drugs toxins infections cerebrovascular diseases and metabolic diseases; 2. complicated with other major diseases such as liver and kidney blood immune system; 3. Participating in other drug clinical trials at the same time; 4. those with severe mental illness who are unable to cooperate; 5. Unable to cooperate with fNIRS examination or have contraindications to fNIRS examination; 6. other patients who did not meet the diagnostic and inclusion criteria.