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Comparing antidepressants in Parkinson's

This study compares bupropion and sertraline for depression in people with Parkinson's.

Testing a treatment or activity · Study reference: IRCT20200513047429N1

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported date)
2020-06-09

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

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Papers connected to this study

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Who can join?

Age range not listed · Ask the team who can join

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Sex eligibility reported by registry: both

Inclusion criteria: Parkinson's patients with major depression, Exclusion criteria: Absence history of other major neurological disorders, such as epilepsy, head trauma, vascular disorders, stroke and dementia, and other major psychiatric disorders, including bipolar disorder, schizophrenia, substance abuse, and use of Antipsychotics in the last 6 months
Full study name & original research details

Official study title

Comparison of the effect of Bupropion with sertraline on the treatment of depression in Parkinson patients.

Short title used by the registry

Comparison Bupropion with srtraline on the depression in Parkinson

Original description

Intervention: Intervention 1: Intervention group 1: Depressed Parkinson's patients will be prescribed Bupropion tablets at an initial dose of 75 mg daily, and if there is no initial response after one month, the dose will be increased to 150 mg daily. The above drug is manufactured by Abidi Pharmaceutical Company. Intervention 2: Intervention group: Depressed patients with Parkinson's disease, Sertraline at a dose of 50 mg daily, and if there is no initial response after one month, an increase in dose to 100 mg daily will be prescribed. It is an drug from Abidi Pharmaceutical Company. Primary outcome: Severity of depression based on Beck's questionnaire. Timepoint: Measuring depression before intervention and then 1 and 3 month after intervention. Method of measurement: Beck's depression questionnaire.

Conditions reported: Condition 1: Depression. Condition 2: Parkinson. Other depressive episodes Parkinson's disease;F32.8

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Intervention 1: Intervention group 1: Depressed Parkinson's patients will be prescribed Bupropion tablets at an initial dose of 75 mg daily, and if there is no initial response after one month, the dose will be increased to 150 mg daily. The above drug is manufactured by Abidi Pharmaceutical Company. Intervention 2: Intervention group: Depressed patients with Parkinson's disease, Sertraline at a dose of 50 mg daily, and if there is no initial response after one month, an increase in dose to 100 mg daily will be prescribed. It is an drug from Abidi Pharmaceutical Company.
Phases
4
Sponsor
Tehran University of Medical Sciences
Start date reported by registry
2020-06-09 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Fayazi Ashraf · +98 21 6649 2271 · tums_edu@tums.ac.ir

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Iran (Islamic Republic of)

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.