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Botulinum toxin injections into hand muscles

Researchers are testing injections alongside usual Parkinson's medicines and measuring their effects.

Testing a treatment or activity · Study reference: IRCT20100127003217N11

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date)
2019-02-19

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 30 years to 85 years · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: both

Inclusion criteria: Patients with idiopathic or familial Parkinson's disease (Parkinson's disease or PD); age between 30 to 85 years, one year after definitive diagnosis; patients with PD who have hand tremor (single-sided or bilateral). Patients with PD who are in stages I-III of Hoehn & Yahr staging . Patients with PD who are being treated with routine anti-Parkinson drugs, especially levodopa. Patients with PD who are willing to participate in the study and are satisfied with botulinum toxin injections. Exclusion criteria: Patients with PD who have had cognitive impairment or psychosis Patients with PD who have had a history of botulinum Toxin injection or any other injection over the past four months Patients with PD who have had a history of surgery (DBS: deep brain stimulation) Patients with secondary Parkinsonism, such as Pharmaceutical Parkinsonism Patients with hand tremor which is resulting from a medical condition, such as antipsychotic drugs Pregnancy and breastfeeding
Full study name & original research details

Official study title

Therapeutic effectiveness of local Botulinum toxin injection on hand tremor severity and upper limb function in patients with Parkinson disease_ a randomized clinical trial

Short title used by the registry

The Effect of Local Injection of Botulinum Toxin in Parkinson's Patients

Original description

Intervention: Intervention 1: Intervention group: injection of diluted Botulinum toxin in the affected hand muscles in addition to Parkinson's routine oral medicine.According to studies conducted so far, 7 muscles from 14 common muscles have been injected in more than 80% of patients, including Flexor Carpi Radialis (FCR), Flexor Carpi Ulnaris (FCU), Pronator Tres, Pronator Quadratous, Extensor Caripi Radialis Longus (ECRL) and Extensor Carpi Ulnaris (ECU) and Supinator. The injectable dose is selected for each muscle depending on the moderate and standard deviation of previous successful efforts (15 ± 5 units of botulinum toxin). According to available resources and general consensus and prevention of severe weakness, to each specified muscles of the forearm flexor, 20 units of Botulinum toxin are injected and to each prescribed muscles of the forearm extensor should be injected 10 to 15 units of Botulinum toxin. Intervention 2: Control group: 10 people in the control group received only Parkinson’s routine oral medication. Primary outcome: Clinical severity of hand tremor. Timepoint: At the beginning of the study and before the intervention, 1.5 months, 4 months after injection. Method of measurement: 2 questionnaires including FTM (Fahn_Tolosa_Marin Temor Rating Scale) and UPDRS (Unified Parkinsone Disease Rating Scale). Secondary outcome: Functional severity of hand tremor. Timepoint: At the beginning of the study and before the intervention, 1.5 months, 4 months after injection. Method of measurement: ADL questionnaire from Bain and Findley questionnaire, manual dynamometer, 10 euro coin test.

Conditions reported: Parkinson's Disease. Parkinson's disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Intervention 1: Intervention group: injection of diluted Botulinum toxin in the affected hand muscles in addition to Parkinson's routine oral medicine.According to studies conducted so far, 7 muscles from 14 common muscles have been injected in more than 80% of patients, including Flexor Carpi Radialis (FCR), Flexor Carpi Ulnaris (FCU), Pronator Tres, Pronator Quadratous, Extensor Caripi Radialis Longus (ECRL) and Extensor Carpi Ulnaris (ECU) and Supinator. The injectable dose is selected for each muscle depending on the moderate and standard deviation of previous successful efforts (15 ± 5 units of botulinum toxin). According to available resources and general consensus and prevention of severe weakness, to each specified muscles of the forearm flexor, 20 units of Botulinum toxin are injected and to each prescribed muscles of the forearm extensor should be injected 10 to 15 units of Botulinum toxin. Intervention 2: Control group: 10 people in the control group received only Parkinson’s routine oral medication.
Phases
4
Sponsor
Tabriz University of Medical Sciences
Start date reported by registry
2019-02-19 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Dr. Leila Fallah · +98 41 3337 3967 · dr_fallah.leila@yahoo.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Iran (Islamic Republic of)

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.