Recruiting · registry statusMapping the brain's movement areas
This study uses magnetic stimulation to investigate how brain areas involved in movement work in Parkinson's.
Learning by observing or collecting information · Study reference: DRKS00038046
Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓
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Looking for volunteers
- Start (reported date)
- 2025-12-08
Planned dates can move. A study finishing does not tell us when a paper will be published.
No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.
Changes we have recorded
These are dates we observed a change, not necessarily the dates it happened.
Papers connected to this study
No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.
Who can join?
Age 18 years and over · Ask the team who can join
These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.
Read all the rules for taking part
Sex eligibility reported by registry: all
Inclusion criteria: Healthy participants (Study Part 1):
No neurological, psychiatric, or internal medical disorders
Age > 18 years
Right-handed: Edinburgh Handedness Inventory Test
No cognitive impairment: Montreal Cognitive Assessment (MoCA) > 25
No motor deficits: UPDRS III = 1
Capacity to provide informed consent
Understanding of the study procedures and written informed consent to participate
Patients with Parkinson’s disease (Study Parts 2 and 3):
Diagnosis of Parkinson’s disease
Treatment with deep brain stimulation (DBS) using directional electrodes
Either completion of follow-up visits approx. 3 months and 12 months after DBS surgery or consent to participate in follow-up visits approx. 3 months and 12 months after DBS surgery (part of routine clinical care at our center)
Age > 40 years
Capacity to provide informed consent
Understanding of the study procedures and written informed consent to participate
Patients with ALS (Study Part 4):
Age > 18 years
Clinically confirmed diagnosis of ALS according to the Gold Coast criteria
Capacity to provide informed consent
Understanding of the study procedures and written informed consent to participate
Exclusion criteria: Healthy participants:
Parkinson’s disease or other severe neurological, internal medical, or psychiatric disorders
Reduced cognitive abilities: MoCA < 25
Implants causing significant ferromagnetic artifacts (which would make MEG analysis impossible), such as tattoos containing metal, pacemakers, defibrillators, implanted pumps, and other interfering metallic implants
Large head circumference preventing comfortable positioning within the MEG helmet
Claustrophobia
Patients with Parkinson’s disease:
Additional severe neurological, internal medical, or psychiatric disorders
Reduced cognitive abilities: MoCA < 25
Implants causing significant ferromagnetic artifacts (which would make MEG analysis impossible), such as tattoos containing metal, pacemakers, defibrillators, implanted pumps, and other interfering metallic implants, with the exception of the DBS system
Large head circumference preventing comfortable positioning within the MEG helmet
Claustrophobia
Patients with ALS:
Additional severe neurological, internal medical, or psychiatric disorders
Implants causing significant ferromagnetic artifacts (which would make MEG analysis impossible), such as tattoos containing metal, pacemakers, defibrillators, implanted pumps, and other interfering metallic implants
Large head circumference preventing comfortable positioning within the MEG helmet
Claustrophobia
Full study name & original research details
Official study title
Electrophysiological mapping of the motor cortex in disorders of the corticomotoneuronal and extrapyramidal motor systems
Original description
Intervention:
Group 1: In this prospective study, we aim at mapping the electrophysiological architecture of the motor cortex using non-invasive Magnetoencephalography (MEG). Brain activity is acquired using MEG during simple movements of tongue, hand, and foot. There will be 30 repetitions (movement executions) per body part, which corresponds to 90 movements for the three body parts being examined. With a duration of 3 seconds per movement and a 3-second break between movements, this results in a total duration of approximately 10 minutes per block. This sequence is to be carried out six times. Finally, 5 minutes of resting-state data are recorded. The total measurement time is therefore about 60 minutes (6 × 10 min + 5 min). In addition, there are approximately 30 minutes of preparation time as well as breaks. Altogether, the entire procedure takes about 120 minutes.This is a cross-sectional study with a single study session.
Primary outcome:
The aim of this study is to map the functional organization of the motor cortex electrophysiologically using non-invasive magnetoencephalography (MEG). The specific objectives are:
1.) To map the functional electrophysiological architecture of M1 in healthy humans based on movement-associated neural activity.
Secondary outcome:
2.) To investigate changes in the functional electrophysiological architecture of M1 in Parkinson’s disease as a model disorder of the extrapyramidal motor system, and to examine the effects of deep brain stimulation on this architecture.
3.) To conduct an exploratory analysis of the functional electrophysiological architecture of M1 in individuals with a disease of the cortico-motoneuronal system (ALS).
Conditions reported: G20
G12;Parkinson disease;Spinal muscular atrophy and related syndromes
Registry records for this study
Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.
- Study type
- Observational
- Interventions
- Group 1: In this prospective study, we aim at mapping the electrophysiological architecture of the motor cortex using non-invasive Magnetoencephalography (MEG). Brain activity is acquired using MEG during simple movements of tongue, hand, and foot. There will be 30 repetitions (movement executions) per body part, which corresponds to 90 movements for the three body parts being examined. With a duration of 3 seconds per movement and a 3-second break between movements, this results in a total duration of approximately 10 minutes per block. This sequence is to be carried out six times. Finally, 5 minutes of resting-state data are recorded. The total measurement time is therefore about 60 minutes (6 × 10 min + 5 min). In addition, there are approximately 30 minutes of preparation time as well as breaks. Altogether, the entire procedure takes about 120 minutes.This is a cross-sectional study with a single study session.
- Phases
- Not reported
- Sponsor
- Universitätsklinikum Düsseldorf
- Start date reported by registry
- 2025-12-08 (reported)
Registry updated: Not reported · Status last verified by the registry submitter: Not reported
Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.
Contact the research team
Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.
Bahne Tenge-Bahners · 0211/81-16756 · bahne.bahners@med.uni-duesseldorf.de
Study locations
Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.
Facility not reported
Germany
Status not reportedThe original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.