Recruiting · registry status

Choosing settings for deep brain stimulation

Researchers are comparing approaches guided by brain anatomy or electrical signals and asking which patients prefer.

Testing a treatment or activity · Study reference: DRKS00037920

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date): 2025-10-15

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

Anatomically vs. eLectrophysIologically Guided Contact SelectioN in Deep Brain Stimulation for Parkinson’s Disease (ALIGN-PD): Study Protocol for a Randomized Double-blind Crossover Trial
This paper mentions the study ID; the relationship needs review · 2025

Who can join?

Age 18 years and over · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: male

Inclusion criteria: Clinically established diagnosis of Parkinson’s disease Bilateral implantation of directional electrodes for deep brain stimulation in the subthalamic nucleus at least 10 weeks prior to study start Stimulation system capable of adaptive stimulation (Medtronic Percept RC/PC) Oral and written informed consent Stable Parkinson’s disease–specific medication for at least two weeks prior to study start Exclusion criteria: Clinically relevant cognitive impairment Levodopa dysregulation syndrome Severe affective disorder Inability or unwillingness to independently switch stimulation programs using the patient controller Insufficient image quality of perioperative clinical imaging (cMRI/cCT) for reconstruction of the individual electrode position

Full study name & original research details

Official study title

Anatomically vs. eLectrophysIologically Guided Contact SelectioN in Deep Brain Stimulation for Parkinson’s Disease - ALIGN PD

Short title used by the registry

Anatomically vs. eLectrophysIologically Guided Contact SelectioN in Deep Brain Stimulation for Parkinson’s Disease

Original description

Intervention: Group 1: anatomy-based continuous deep brain stimulation (aicDBS) Group 2: adaptive deep brain stimulation (aDBS) Primary outcome: Subjective preference of patients between anatomy-based stimulation (aicDBS) and adaptive stimulation (aDBS) Secondary outcome: Therapy-associated changes in motor and non-motor symptoms assessed by questionnaires and continuous accelerometry, as well as electrophysiological data recorded via the deep brain stimulation electrode

Conditions reported: G20;Parkinson disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

German Clinical Trials Register · DRKS00037920 ↗ — Recruiting; WHO ICTRP processed 2026-01-12; checked 2026-10-14

Study type: Interventional
Interventions: Group 1: anatomy-based continuous deep brain stimulation (aicDBS) Group 2: adaptive deep brain stimulation (aDBS)
Phases: 4
Sponsor: Universitätsklinikum Köln, Klinik und Poliklinik für Neurologie
Start date reported by registry: 2025-10-15 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Michael Thomas Barbe · 0221 478 7494 · michael.barbe@uk-koeln.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Germany

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.