Recruiting · registry status

Toothbrushing and oral care in Parkinson's

Researchers are observing brushing to understand how Parkinson's symptoms affect cleaning teeth effectively.

Testing a treatment or activity · Study reference: DRKS00032845

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported date): 2025-04-01

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No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

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Papers connected to this study

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Who can join?

Age 18 years and over · Ask the team who can join

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Sex eligibility reported by registry: all

Inclusion criteria: - Parkinson's disease diagnosis with akinetic-rigid type (n=40), specialist diagnosis - Höhn and Yahr>=2 - healthy control subjects (n=40) without neurodegenerative diseases - Regular use of a manual toothbrush for self-performed oral hygiene at home - = 10 natural teeth - Interest and consent to participate in the study Exclusion criteria: - Preexisting conditions that have a direct impact on manual dexterity (e.g. hemiparesis, pronounced arthrosis, gout on the upper extremities) - rejection of oscillating electric toothbrushes or electronic aids for self-performed oral hygiene - Höhn&Yahr 5 - Dementia (MOCA-instrument)

Full study name & original research details

Official study title

Parkinson-related factors influencing the ability of optimal biofilm control - PATROL

Short title used by the registry

Parkinson-related factors influencing the ability of optimal biofilm control

Original description

Intervention: Group 1: Phase A) Case-control design Exploratory video analysis of toothbrushing behavior of patients with Parkinson's disease (akinetic-rigid type) Group 2: Phase A) Case-control design Explorative video analysis of the toothbrushing behavior of healthy control subjects Group 3: Phase B) Cross-over design Investigation of plaque reduction ability by using an electric oscillating toothbrush compared to a manual toothbrush in the case group (patients with Parkinson's disease) All participants use both types of toothbrush - either in the order “electric toothbrush - manual toothbrush” or in the order “manual toothbrush - electric toothbrush”. The individual brushing phases last 4 weeks for each toothbrush. During the brushing phases, the teeth are brushed daily. There is a break (wash-out phase) of 3 weeks between the change of intervention. Primary outcome: Phase A) The explorative analysis of the cleaning behavior of participants with Parkinson's disease and healthy controls shows differences Phase B) The 4-week use of an electric toothbrush leads to a lower plaque index (QHI) in people with Parkinson's disease than the use of a manual toothbrush. (mean plaque index) Secondary outcome: Phase A) The plaque reduction competence measured with the QHI before and after brushing is significantly greater in healthy controls than in participants with Parkinson's disease. (mean plaque index) Phase B) The 4-week use of an electric toothbrush leads to a lower gingivitis index (P gingivitis index (PBI) than the use of a manual toothbrush. (mean gingivitis index)

Conditions reported: G20;Parkinson disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

German Clinical Trials Register · DRKS00032845 ↗ — Recruiting; WHO ICTRP processed 2025-12-08; checked 2026-10-14

Study type: Interventional
Interventions: Group 1: Phase A) Case-control design Exploratory video analysis of toothbrushing behavior of patients with Parkinson's disease (akinetic-rigid type) Group 2: Phase A) Case-control design Explorative video analysis of the toothbrushing behavior of healthy control subjects Group 3: Phase B) Cross-over design Investigation of plaque reduction ability by using an electric oscillating toothbrush compared to a manual toothbrush in the case group (patients with Parkinson's disease) All participants use both types of toothbrush - either in the order “electric toothbrush - manual toothbrush” or in the order “manual toothbrush - electric toothbrush”. The individual brushing phases last 4 weeks for each toothbrush. During the brushing phases, the teeth are brushed daily. There is a break (wash-out phase) of 3 weeks between the change of intervention.
Phases: N/A
Sponsor: Poliklinik für Zahnerhaltung und Parodontologie, Zentrum für Zahn-, Mund- und Kieferheilkunde, Uniklinik Köln
Start date reported by registry: 2025-04-01 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Annette Froitzheim · +49 221 478 96743 · annette.froitzheim@uk-koeln.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Germany

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.