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Gut bacteria and the body's use of energy

Researchers are examining metabolism, health and gut microbes in people with Parkinson's.

Learning by observing or collecting information · Study reference: DRKS00030597

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported date)
2023-04-17

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 20 years and over · Ask the team who can join

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Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion criteria: •BMI 18,5-39,9 kg/m² •Non-smoker (for at least 3 months) written declaration of consent for participation in the study. •Diagnosis Parkinson disease or Alzheimer disease PD cohort: •PD based on clinical diagnosis according to Brain Bank criteria(Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease. A clinico-pathological study of 100 cases. JNNP 1992;55:181-184.) •Hoehn & Yahr stadium 1-3 AD cohort •Clinical and biomarker-based diagnosis with Alzheimer's pathology based on typical CSF findings Mixed dementia with a vascular component (up to Fazekas II) is permitted. Exclusion criteria: •Taking medications that affect glucose metabolism •chronic inflammatory bowel or liver diseases •antibiotic therapy 3 weeks before the start of the study •Planned lifestyle changes •regular intake of supplements •drug abuse •participation in another clinical trial simultaneously/in the last 30 days PD cohort: •Atypical PD syndromes •DBS care •severe motor fluctuations AD cohort: •Dementia of unclear origin •Heavy vascular part (Fazekas III)
Full study name & original research details

Official study title

Metabolic health in neurodegenerative diseases - implications of metabolic characteristics and gut microbiome - NeuroBiom

Short title used by the registry

Metabolic health in neurodegenerative diseases - implications of metabolic characteristics and gut microbiome

Original description

Intervention: Group 1: People with Parkinson disease Participation in the study consists of two visits. On visit 1, inclusion in the study takes place after the inclusion and exclusion criteria have been checked. In addition, a detailed explanation of the study measurements is done and study questionnaires are handed out (duration approx. 1.5 h). At visit 2, a 3-h oral glucose tolerance test, anthropometric measurements and questionnaires are performed (for details see endpoints; duration approx. 5 h). Optionally, subjects could participate in two further study days, on which a 3-h mixed-meal tolerance test (MMTT) or 3-h fasting state observation are conducted (duration approx. 3.5 h). Group 2: People with Alzheimer disease The study procedure is identical to that described for Arm 1. Group 3: People with metabolic syndrome The study procedure is identical to that described for Arm 1. Primary outcome: Metabolic differences Secondary outcome: intestinal microbiome (composition, diversity), concentration of various intestinal hormones, parameter of intestinal permeability, parameter of glucose and lipid metabolism, parameter of inflammation, neuroinflammation and antioxidative defence, short chain fatty acids (SCFAs), amino acids, serotonin, electrolytes. Further parameters: anthropometrics (body weight, body height, waist and hip ratio, body composition (BodPod), resting energy expenditure (QuarkRMR), cognition, transit time, nutritional behaviour, physical activity, socio-economic status, chronobiology, gynaecological history. Security parameters: small blood count, parameters of renal and hepatic function (GOT, GPT, GGT, bilirubin, uric acid, urea, creatinine).

Conditions reported: G20 G30 E88.9;Parkinson disease;Alzheimer disease;Metabolic disorder, unspecified

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Group 1: People with Parkinson disease Participation in the study consists of two visits. On visit 1, inclusion in the study takes place after the inclusion and exclusion criteria have been checked. In addition, a detailed explanation of the study measurements is done and study questionnaires are handed out (duration approx. 1.5 h). At visit 2, a 3-h oral glucose tolerance test, anthropometric measurements and questionnaires are performed (for details see endpoints; duration approx. 5 h). Optionally, subjects could participate in two further study days, on which a 3-h mixed-meal tolerance test (MMTT) or 3-h fasting state observation are conducted (duration approx. 3.5 h). Group 2: People with Alzheimer disease The study procedure is identical to that described for Arm 1. Group 3: People with metabolic syndrome The study procedure is identical to that described for Arm 1.
Phases
Not reported
Sponsor
Klinik für Parkinson, Schlaf- und Bewegungsstörungen, Zentrum für Neurologie, Universitätsklinikum Bonn
Start date reported by registry
2023-04-17 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Janis Bedarf · 0049 228 287 13091 · janis.bedarf@ukbonn.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Germany

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.