Following quality of life for people and families

Inclusion criteria: Patients suffering from a clinical diagnosis of iPD according to the recent clinical diagnostic criteria (MDS criteria) iPD-stages of I – IV according to the Hoehn & Yahr scale (in the OFF state, i.e., without medication) Patients aged between between 30 and 100 years Patients with the ability to provide informed consent. In cases where participants lose their capacity to consent at follow-up visits (e.g., due to dementia, etc.), this participant will only be allowed to continue if a legal representative (proxy, guardian) provides informed consent to further par- ticipation on behalf of the participant. In this case, the legal representatives will be provided with a separate consent form Exclusion criteria: Patients suffering from a clinical diagnosis of atypical Parkin- son’s syndrome in a first instance. Patients enrolled who were later characterized as atypical Parkinson syndroms will not be excluded. iPD-stages of V according to the Hoehn & Yahr scale (in the OFF stage, i.e. without medication) The use of magnetic fields in the MRI examination excludes the participation of persons who have electrical devices (e.g., cardiac pacemakers, medication pumps, etc.) or metal parts (e.g., screws after bone fracture) in or on their bodies Women who are pregnant will not receive MRI. Subjects who do not want to be informed about possible incidental findings are also not allowed to participate in the imaging part of the study