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Brain changes after larger-movement training

Researchers are studying LSVT BIG exercise, walking and brain activity in Parkinson's.

Testing a treatment or activity · Study reference: DRKS00008732

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date)
2015-09-15

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 25 years to 80 years · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion criteria: Patients (Gender masculin or feminin) with the clinical diagnosis of an idiopathic parkinson syndrome. Age between 25 and 80 years. Good german language skills. Patients need to be capable to consent and have to sign a consent. Exclusion criteria: Patients, who suffer under another disease that affects their cognition (for example vascular disease, Tumor). Patients with strong depression (BDI over 29 points) and/or dementia (Panda 20 %) in the last 6 months. Pulmonary embolism, myocardial infarct, endocarditis in the last 3 months. Haemodynamic relevant stenosis of aortic valve and/or mitralic valve.
Full study name & original research details

Official study title

Neuronal plasticity of network topography in parkinson disease through LSVT-BIG therapy

Original description

Intervention: Group 1: 20 patients receive LSVT-BIG therapy for 4 weeks (4x 60 min per week). Before and after the 4 weeks of therapy, half of them gets an rs-fMRI. All of them need to do a gangway-test ( three times with and three times without shoes), the chair-rising-test (three times), UPDRS III, NMS, PDQ-39, AES, BDI-2, MMST and the Panda. Group 2: 20 patients receive intensive physiotherapy for 4 weeks (4x 60 min per week). Before and after the 4 weeks of therapy, half of them gets an rs-fMRI. All of them need to do a gangway-test ( three times with and three times without shoes), the chair-rising-test (three times), UPDRS III, NMS, PDQ-39, AES, BDI-2, MMST and the Panda. Group 3: 20 patients receive normal physiotherapy for 8 weeks (2x 30 min per week). Before and after the 4 weeks of therapy, half of them gets an rs-fMRI. All of them need to do a gangway-test ( three times with and three times without shoes), the chair-rising-test (three times), UPDRS III, NMS, PDQ-39, AES, BDI-2, MMST and the Panda. Primary outcome: Improvement of non-motor-symptoms before and after the physiotherapy. Evaluation through the NMS-Score in the week before and after the therapy. Socre is taken in the week before and after the physiotherapy. Secondary outcome: - Motoric functions (UPDRS III), video hast to be recorded baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. Evaluation by two persons. - Psychometric functions (BDI-2, AES, PANDA and MMST). Questionnaires have to be answered baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. -PDQ-39 evaluates quality of life. Questionnaire has to be answered baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. - ReHo/Fc rs-fMRI with the focus on the motoric network activity and core theme on the premotoric cortex, SMA, primary sensomotoric cortex, putamen and cerebellum, rs-fMRI has to be done in the week before and after the physiotherapy at the same time.

Conditions reported: G20;Parkinson disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Group 1: 20 patients receive LSVT-BIG therapy for 4 weeks (4x 60 min per week). Before and after the 4 weeks of therapy, half of them gets an rs-fMRI. All of them need to do a gangway-test ( three times with and three times without shoes), the chair-rising-test (three times), UPDRS III, NMS, PDQ-39, AES, BDI-2, MMST and the Panda. Group 2: 20 patients receive intensive physiotherapy for 4 weeks (4x 60 min per week). Before and after the 4 weeks of therapy, half of them gets an rs-fMRI. All of them need to do a gangway-test ( three times with and three times without shoes), the chair-rising-test (three times), UPDRS III, NMS, PDQ-39, AES, BDI-2, MMST and the Panda. Group 3: 20 patients receive normal physiotherapy for 8 weeks (2x 30 min per week). Before and after the 4 weeks of therapy, half of them gets an rs-fMRI. All of them need to do a gangway-test ( three times with and three times without shoes), the chair-rising-test (three times), UPDRS III, NMS, PDQ-39, AES, BDI-2, MMST and the Panda.
Phases
N/A
Sponsor
Uniklinik Köln
Start date reported by registry
2015-09-15 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

cand. med. Fabian Schaible · 015735141244 · fabian.schaible@uk-koeln.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Germany

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.