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Brain rhythms and treatment in Parkinson's

This study uses brain and muscle recordings to investigate movement-related signals and how treatment affects them.

Testing a treatment or activity · Study reference: DRKS00006257

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date)
2014-08-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 30 years to 80 years · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion criteria: Healthy subjects: • Male and female participants between 30 and 80 years of age • Right handed persons • Capability of signing an informed consent Parkinson’s patients: • Male and female patients with the diagnosis of an IPS according to the guidelines of the DGN • Right handed patients • Patients with the indication for receiving deep brain stimulation (target areas: STN, GPi, Vim) with uncontrollable motor symptomes due to strong dyskinesia and/ or ON/OFF fluctuations • positive motor response to L-Dopa or Apomorphine; • Patients between 30 and 80 (in order to exclude genetic variants of the disease); • time period of the symptomes longer than 4 years (differential diagnosis); • patients have to be able to sign an informed consent; • Ability to cooperate during the measurements Exclusion criteria: Healthy subjects: • non- ""sui juris"" patients, underaged persons as well as subjects which are judically sent to an institution • diagnosis of an idiopathic parkinson syndrom or any other neurological disease • participants that take drugs regularly which influence the nervous system and which can not be stopped the evening before the experiment • severe internal comorbidities • presence of psychiatric diseases •impaired vision or hearing defect that may hinder the testing • pregnant or breast feeding mothers Parkinson’s patients: • non- ""sui juris"" patients, underaged persons as well as subjects which are judically sent to an institution • patients that suffer from another neurological disease apart from Parkinsons like Epilepsy, Alzheimers or Dystonia • patients with severe frontal executive disturbances • presence of a Parkinson-Plus-Syndrom like corticobasal degeneration, progressive supranuclear palsy or multisystem atrophy • other hypokinetic movement disorders like MPTP- or manganese intoxication, chorea Huntington, subcortical arteriosclerotic encephalopathy or psychogenic movement disorder • clinically relevant abnormalities in preoperative MR-Images like ischemia, or cerebral athropy • previous surgeries in the ZNS due to, for example, brain tumors, epilepsy or vascular reasons • severe internal comorbidities • presence of psychiatric diseases • impaired vision or hearing defect that may hinder the testing • pregnant or breast feeding mothers
Full study name & original research details

Official study title

Neuronal osciallations in basal-ganglia-loops and their therapeutic modulation in patients with idiopathic Parkinson syndrome.

Original description

Intervention: Group 1: healthy volunteers, age-matched (EEG recording with a 128-channel-system from the head surface and synchronous measurment of the EMG from the right forearm during the conduction of simple movments) Group 2: Parkinsons-Patients (pre- and posteroperatively EEG-recording with a 128 channel system from the head surface, synchronous recording of the EMG from the right forearm during the conduction of simple movements; intraoperatively: the above mentioned electrophysiological measurements will be accompanied by the recording of local field potentials as well as single cell activity from the target structures of deep brain stimulation using microelectrodes; perioperatively, in addition to EEG and EMG, local field potentials will be recorded by the use of externalized electrodes) Primary outcome: Pathological, oscillatory coupling between EEG and EMG in the beta range (13-30 Hz) on different measurement days without treatment Secondary outcome: Comparision of pathological, electrophysiological acitivity for two Parkinsons-Subtypes (tremor-dominant versus akinetic rigid)

Conditions reported: G20;Parkinson disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Group 1: healthy volunteers, age-matched (EEG recording with a 128-channel-system from the head surface and synchronous measurment of the EMG from the right forearm during the conduction of simple movments) Group 2: Parkinsons-Patients (pre- and posteroperatively EEG-recording with a 128 channel system from the head surface, synchronous recording of the EMG from the right forearm during the conduction of simple movements; intraoperatively: the above mentioned electrophysiological measurements will be accompanied by the recording of local field potentials as well as single cell activity from the target structures of deep brain stimulation using microelectrodes; perioperatively, in addition to EEG and EMG, local field potentials will be recorded by the use of externalized electrodes)
Phases
N/A
Sponsor
Uniklinik Köln, NeurologieArbeitsgruppe für Bewegungsstörungen und Tiefe Hirnstimulation
Start date reported by registry
2014-08-01 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Elfriede Stubbs · 0221-478-98842 · elfriede.stubbs@uk-koeln.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Germany

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.