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Detailed brain structure in Parkinson's and similar conditions

This study compares magnetic resonance imaging measurements across several movement disorders.

Learning by observing or collecting information · Study reference: DRKS00003454

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported date)
2012-01-12

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 years to 85 years · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion criteria: Patients with parkinson's disease, multiple system atrophy, cortico-basal degeneration, progressive supranuclear palsy or dementia with lewy bodies who are willing to participate at any state of the disease. Controls will be without neurological disease, matched for age. Exclusion criteria: Contraindications against MRI as huge tatoos, implants as pace makers, impulse generators etc.
Full study name & original research details

Official study title

Combined diffusion tensor imaging (DTI, global fiber tracking and voxel based morphometry (VBM) in patients with idiopathic or atypical Parkinson syndrome

Original description

Intervention: Group 1: Patients suffering from IPD and atypical Parkinson syndromes like multiple system atrophy, progressive supranuclear palsy, cortico-basal degeneration, or dementia with lewy-bodies. Clinical Tests: UPDRS I-III; Hoehn and Yahr; Non-motor symptoms questionaire (NMS-Quest) and scale (NMS-Scale); Montreal Cognitive Assessment (MoCA), Beck Depression Inventar (BDI). MRI-sequences: DTI, SWI, resting state, T1 MP-Rage. Group 2: Controls. Clinical Tests: Montreal Cognitive Assessment (MoCA), Beck Depression Inventar (BDI). MRI-sequences: DTI, SWI, resting state, T1 MP-Rage. Primary outcome: Detecting the degeneration of the fibre tracts via MRI DTI (diffusion tensor imaging) sequences using global fibre tracking, Comparison of the fibre tracts by voxel based morphometry (VBM), resting-state sequences are performed to test the functionality of these tracts.

Conditions reported: G20 G23;Parkinson disease;Other degenerative diseases of basal ganglia

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Group 1: Patients suffering from IPD and atypical Parkinson syndromes like multiple system atrophy, progressive supranuclear palsy, cortico-basal degeneration, or dementia with lewy-bodies. Clinical Tests: UPDRS I-III; Hoehn and Yahr; Non-motor symptoms questionaire (NMS-Quest) and scale (NMS-Scale); Montreal Cognitive Assessment (MoCA), Beck Depression Inventar (BDI). MRI-sequences: DTI, SWI, resting state, T1 MP-Rage. Group 2: Controls. Clinical Tests: Montreal Cognitive Assessment (MoCA), Beck Depression Inventar (BDI). MRI-sequences: DTI, SWI, resting state, T1 MP-Rage.
Phases
Not reported
Sponsor
Neurologische Universitätsklinikum Freiburg
Start date reported by registry
2012-01-12 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-14 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Florian Amtage · +49 761 270 50010 · florian.amtage@uniklinik-freiburg.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Germany

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.