Longer-term safinamide treatment early in Parkinson's

Inclusion criteria: Inclusion Criteria: To be eligible for inclusion into this trial, the subjects must fulfill all of the following criteria: 1. The subject completed 24 weeks of Trial 27918. 2. The subject successfully completed all trial requirements in Trial 27918. 3. If female, they must be either post-menopausal for at least 2 years, surgically sterilized or have undergone hysterectomy or, if of child bearing potential they must be willing to avoid pregnancy by using an adequate method of contraception for four weeks prior to, during and four weeks after the last dose of trial medication. For the purposes of this trial, women of childbearing potential are defined as: ?All female subjects after puberty unless they are post-menopausal for at least two years, are surgically sterile or are sexually inactive?. 4. Subject is willing and able to participate in the trial and has provided written, informed consent Exclusion criteria: 1. If female, the subject is pregnant or lactating. 2. The subject experienced a clinically significant adverse effect during Trial 27918 that could put the subject at risk according to the investigator?s opinion. 3. The subject has shown clinically significant deterioration during participation in Trial 27918. 4. Motor deterioration during trial 27918 that required upward titration of existing antiparkinsonian medication or the initiation of an additional anti-parkinsonian medication. 5. The investigator deems it is not in the subject?s best interest to participate to trial 27938. 6. Signs and symptoms suggestive of transmissible spongiform encephalopathy, or family members who suffer(ed) from such.