Photodynamic Therapy for Parkinson's Disease: Neuroprotective Mechanisms and Future Prospects
Photodynamic Therapy for Parkinson's Disease: Neuroprotective Mechanisms and Future Prospects
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Original abstract
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized pathologically by the loss of dopaminergic neurons in the substantia nigra pars compacta and the abnormal aggregation of α-synuclein. While traditional treatments like levodopa and deep brain stimulation alleviate symptoms, they do not halt disease progression. Photodynamic therapy (PDT), a technique offering precise spatiotemporal control and minimal invasiveness, has emerged as a potential therapeutic modality for PD. This review highlights the unique advantages of PDT, including its precision, minimal invasiveness, and capacity for the targeted clearance of α-synuclein aggregates, which may underpin its neuroprotective effects. By integrating multi-modal imaging and artificial intelligence, PDT holds promise as a personalized treatment strategy for PD.