Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea
Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Seoul, KR · Author affiliation
Department of Family Medicine/Executive Healthcare Clinic, Severance Hospital Yonsei University College of Medicine Seoul South KoreaLocation evidence
A plain-language reading has not been prepared for this paper yet.
Original abstract
Abstract Background and purpose Previous studies have examined the risk of stroke in patients with Parkinson disease (PD), but the incidence of PD onset among stroke patients and its risk according to severity of poststroke disabilities have scarcely been investigated. This study aims to determine whether the risk of PD is increased among stroke patients using a retrospective cohort with a large population‐based database. Methods We used data collected by the Korean National Health Insurance Service from 2010 to 2018 and examined 307,361 stroke patients and 380,917 sex‐ and age‐matched individuals without stroke to uncover the incidence of PD. Cox proportional hazards regression was used to calculate the hazard ratio (HR) and 95% confidence interval (CI), and the risk of PD was compared according to presence and severity of disability. Results During 4.31 years of follow‐up, stroke patients had a 1.67 times higher risk of PD compared to individuals without stroke (adjusted HR = 1.67, 95% CI = 1.57–1.78). The risk of PD was greater among stroke patients with disabilities than among those without disabilities, even after adjustment for multiple covariates (adjusted HR = 1.72, 95% CI = 1.55–1.91; and adjusted HR = 1.66, 95% CI = 1.56–1.77, respectively). Conclusions Our study demonstrated an increased risk of PD among stroke patients. Health professionals need to pay careful attention to detecting movement disorders as clues for diagnosing PD.