Ensete Superbum (ROXB.) Cheesman: A Rare Medicinal Plant with Neuroprotective and Anti-Parkinson Applications
Ensete Superbum (ROXB.) Cheesman: A Rare Medicinal Plant with Neuroprotective and Anti-Parkinson Applications
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Visakhapatnam, IN · Author affiliation
Department of Pharmacology, Vignan Institute of pharmaceutical, Technology,Duvvada,Visakhapatnam, Andhara Pradresh, India 530049Location evidence
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Original abstract
Parkinson disease (PD) is a progressive, neurodegenerative disease characterized by the loss of dopaminergic neurons, which cause motor and non-motor disabilities.Its pathogenesis includes the oxidative stress, dysfunctions of the mitochondrion, neuroinflammation, and aggregation α-synuclein.Existing treatments offer only symptomatic help and are linked with long-term restriction, which reflects the necessity of safer, multitarget options.Ensetesuperbum (Roxb.)Cheesman is a medicinal plant that is of the Musaceae family and has been used in Indian ethnomedicine to treat inflammation, diabetes and urinary disorders.Phytochemical analysis indicates flavonoids, phenols, alkaloids, tannins, glycosides, which are antioxidants and anti-inflammatory compounds.These compounds can be involved in the neuroprotection process through mitigating oxidative stress, altering the inflammatory processes, and maintaining neuronal viability.This review briefly encapsulates botanical, phytochemical, and pharmacological properties of E. superbum and shows its possible applicability in Parkinson disease.Nevertheless, its therapeutic efficacy and safety still need to be confirmed in the future through additional experimental and clinical research.