Neuroprotective effect of curcumin against reserpine-induced oxidative damage in the cerebellum of mice in an acute model of Parkinson's disease: Combined in vivo study, molecular docking and molecular dynamics
Neuroprotective effect of curcumin against reserpine-induced oxidative damage in the cerebellum of mice in an acute model of Parkinson's disease: Combined in vivo study, molecular docking and molecular dynamics
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Publication status: preprint
A plain-language reading has not been prepared for this paper yet.
Original abstract
Abstract The neuroprotective potential of curcumin was studied in a reserpine-induced model of progressive Parkinsonism in mice. Male Swiss mice were given daily doses of curcumin-III (30 mg/kg b.w), Madopar (120 mg/kg b.w), or a combination of the two substances, plus three doses of reserpine (0.25 mg/kg b.w) spaced 48 hours apart. Motor behaviour was assessed after the last treatment. Histopathological examinations, indicators of oxidative stress, and neuroinflammation were evaluated at the end of treatment. Treatment with curcumin prevented cell damage in the Purkinje cells of the cerebellum and reduced their oxidative state index. As a result, curcumin reduced motor deficiencies in a progressive animal model of Parkinson's disease, most probably due to an antioxidant action. Also, our comparative study revealed that curcumin binding interactions with Catechol-O-MethylTransferase were stronger than those of the Madopar and thirteen van der Waals interactions (Asp141, Asn170, Glu199, Trp38, Pro174, Tyr68, Gly66, Ala67, Glu90, Ser119, Arg146, Gln120 and Ala118) ensured the formation of the Catechol-O-MethylTransferase -Curcumin complex.