Catheter ablation outcomes in monozygotic twins with Wolff-Parkinson-White syndrome and novel TTN/LRP6 variants.
Catheter ablation outcomes in monozygotic twins with Wolff-Parkinson-White syndrome and novel TTN/LRP6 variants.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Taiyuan, CN · Author affiliation
Department of Cardiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.Location evidence
Beijing, CN · Author affiliation
Cardiovascular Division, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.Location evidence
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Original abstract
BACKGROUND: Genetic associations with isolated sporadic Wolff-Parkinson-White syndrome have rarely been reported. We report a rare case of monozygotic twin male children diagnosed with Wolff-Parkinson-White syndrome. METHODS AND RESULTS: Electrophysiological mapping of the monozygotic twin male children revealed an identical accessory pathway located 1 o'clock anterior to the mitral annulus, which were successfully blocked by radiofrequency ablation. Whole-genome sequencing analysis of the monozygotic twin revealed heterozygous mutations in the TTN and LRP6 genes. CONCLUSIONS: These findings highlight the potential role of genetic factors in the development of sporadic Wolff-Parkinson-White syndrome and may contribute to a better understanding of disease mechanisms and the development of treatment strategies.