Oroxylum Indicum (L.) Kurz: Neuroprotective Phytoconstituents and Advanced Anti-Parkinson Thearapeutic Potential
Oroxylum Indicum (L.) Kurz: Neuroprotective Phytoconstituents and Advanced Anti-Parkinson Thearapeutic Potential
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Visakhapatnam, IN · Author affiliation
Department of Pharmacology, Vignan Institute of pharmaceutical Technology,Duvvada,Visakhapatnam,Andhara Pradesh, India 530049Location evidence
IN · Author affiliation · country only
JNTU -GV College of Pharmaceutical sciences, Andhra Pradesh, India 535003Location evidence
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Original abstract
The selective loss of dopaminergic neurons in the substantia nigra the hallmark of parkinson’s disease(PD),a chronic,progressive neurodegenarative condition that causes crippling motor and non motar problems. Traditional medications,especially levodopa, are therefore desperately nedded.Due to its abundance of bioactive flavonoids, particularly baicalein, chrysin,and oroxylin A, Oroxylum indicum(L) kurz, a medicinal plant belonging to the Bignoniaceae family, has become a viable option. These phytoconstituents have strong anti inflammatory, anti-apoptotic, and anti oxidant qualities that directly combat the main pathologies associated with parkison’s disease. Preclinical studies verify that O. indicum extracts significantly protect dopaminergic neurons and restore functional motor results in well-known toxin-induced models,such as MPTP and 6-hydroxydopamine (6-OHIDA). these neuroprotective effects are mediated mechanistically by reducing oxidative stress, suppressing neuroinflammatory cascades, and precisely modifying important signaling pathways, namely NF-kB inhibition and Nrf2 activation.Despite these encouraging results,poor water solubility and restricted blood-brain barrier permeability have historically hindered the clinical translation of O. indicum-derived drugs.These pharmacokinetics constraints have been successfully addressed by recent advancements in nanotechnology -based drug delivery systems,and long-term therapeutic efficacy.The neuroprotective phytoconstituents of O. indicum,their complex modes of action, and the importance of sophisticated formulation techniques in maximizing their anti-parkison potential are all critically assessed in this through analysis. In the end,O.indicum is a very promising natural medicinal platform that merits through clinical trails to determine its safety,effectiveness,and translational fessibility in the treatment of parkinson’s disease.