Exploring the Therapeutic Potential of Polydatin Through Molecular Docking Analysis: Insights into Anti-Cancer, Cardiovascular, and Neuroprotective Properties
Exploring the Therapeutic Potential of Polydatin Through Molecular Docking Analysis: Insights into Anti-Cancer, Cardiovascular, and Neuroprotective Properties
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Publication status: preprint
A plain-language reading has not been prepared for this paper yet.
Original abstract
This study employs molecular docking analysis to investigate the binding interactions of Polydatin (PD) with three key protein targets: UXS1 (UDP-Glucuronate Decarboxylase 1), Myeloperoxidase, and Monoamine Oxidase B (MAO B). The analysis reveals strong binding energies of -10 kcal/mol, indicating significant affinity between PD and these targets. Our previous preprint highlights PD's potential as an effective anti-cancer agent, particularly through its robust binding with UXS1. Addi tionally, our findings demonstrate effective binding of PD to Myeloperoxidase, suggesting its rele vance in cardiac research, and to MAO B, indicating potential implications in Parkinson's disease management. These results underscore the promising anti-cancer, cardiovascular, and neuroprotective properties of Polydatin.