Die moderne medikament�se Behandlung des Parkinsonismus
Die moderne medikament�se Behandlung des Parkinsonismus
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Original abstract
Evolution, procedure, results and side effects of modern anti-Parkinson treatment are reported. A notable decrease of dopamin, serotonin and norepinephrin in the brainstem of Parkinson patients suggested a substitution of the precursors of these biogenic amines. The administration of L-DCPA effected an improvement in the akinesia for a short time only. A combination of l-DOPA with a decarboxylase inhibitor (Ro4-4602) produced a more intensive effect over a longer period. Similar results were achieved by high oral dosages, accompanied, however, by marked side effects. The autonomic motor and psychogenic side effects are reported. The DOPA-psychoses are caused by the depletion of serotonin after l-DOPA administration. Raised levels of 5-Hydroxyacetic acid were observed in the C.S.F. of psychotic patients. After administration of l-tryptophan the high values of 5 HIAA fell and the patients showed normal behaviour.