Reevaluation von Patienten mit klinischem Verdacht auf Morbus Parkinson und unauffälliger Bildgebung des präsynaptischen dopaminergen Systems
Reevaluation von Patienten mit klinischem Verdacht auf Morbus Parkinson und unauffälliger Bildgebung des präsynaptischen dopaminergen Systems
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Original abstract
Many of the patients presenting a beginning movement disorder primarily diagnosed as Parkinson´s disease were assessed with DAT-Scan or F18-Dopa-PET. As described by other groups, a considerable part of these scans showed not a pattern typical for Parkinson´s disease, but a normal one (called Scans without evidence of dopaminergic deficite or SWEDDS). We present a reevaluation of 16 patients with normal dopaminergic imaging on average 62 month after the imaging. We reevaluated neurological examination, UPDRS, Levodopa-test, Hoehn and Yahr Scale, Schwab and England activites of daily living-scale, Montgomery-Asperg Depression Scale, PDQ39 and Nuernberger Self Evaluation Scales. The goal was to evaluate the clinical outcome and characteristics of patients with a clinically probable Parkinson"s disease but normal DAT-Scan or 18F-Dopa-PET.