Kombinationstherapie mit Rasagilin: Verbesserung der Lebensqualität und motorischen Fluktuationen bei Parkinson-Patienten
Kombinationstherapie mit Rasagilin: Verbesserung der Lebensqualität und motorischen Fluktuationen bei Parkinson-Patienten
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Original abstract
Rasagiline (Azilect®) is a potent, highly selective, irreversible second generation MAO-B inhibitor and is indicated for treatment of idiopathic Parkinson's disease (iPD) as monotherapy (without levodopa) or adjunct therapy (with levodopa). The present 4-month observational study included 754 patients with iPD to investigate efficacy and tolerability of rasagiline in clinical daily practice. The focus was on rasagiline's effects on motor fluctuations and quality of life (QoL) as add-on therapy. 545 patients received 1 mg rasagiline daily as add-on to their regular PD medication. Efficacy criteria were: 1. Columbia University Rating Scale (CURS), 2. clinical fluctuations subscale of the Unified Parkinson's Disease Rating Scale (UPDRS, part IV B), 3.) duration of OffF periods documented in 24-h home diaries, 4. QoL was assessed by Parkinson's Disease Questionnaire (PDQ-39). In 86.6 % of the cases PD medication remained unchanged. Rasagiline was most frequently co-administered with levodopa / DCI (81.7 %) and / or dopamine agonists (65.8 %). The CURS total score improved by 22 %. The improvement rates in CURS items ranged between 31.1 % to 48.4 %. 39 % of the patients experienced a reduction in Off time during the waking period. The duration of Off periods decreased from 120 to 45 minutes. In all aspects of PDQ-39, an improvement in QoL was documented. The total score improved significantly by 7.3 points (20.1 %). Adverse events were reported by 8.4 % of the patients. The add-on medication of rasagiline in patients with iPD resulted in improvements of motor fluctuations and led to an improved quality of life in the self-estimation of the patients.