Erhöhte Frequenzanteile < 0,1 Hertz aus der Posturografie differenzieren zwischen der Progressiven Supranukleären Blickparese und dem idiopathischen Parkinson-Syndrom
Erhöhte Frequenzanteile < 0,1 Hertz aus der Posturografie differenzieren zwischen der Progressiven Supranukleären Blickparese und dem idiopathischen Parkinson-Syndrom
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Original abstract
BACKGROUND Postural instability is an important clinical feature in idiopathic Parkinson syndrome (IPS). The presence of substantial postural instabilities in patients with Parkinson syndrome may lead clinicians to consider the differential diagnosis of progressive supranuclear palsy (PSP). Our aim was to characterise features of postural instability by posturography in patients with IPS and PSP to identify potential markers to differentiate between the two entities. METHODS Posturography (force platform ADDON®) during 20 seconds undisturbed stance in 2 conditions (eyes open, EO; eyes closed, EC) was used to analyse path-time parameters, sway area and frequency power (0.00-3.00 Hz) in patients with IPS (n = 20), probable PSP (n = 6) and an age-matched control group (n = 20). RESULTS Regarding sway area radius, PSP patients differed significantly from IPS and controls (sway area radius: F 2.43 = 10.52; p = 0.000) independent of the visual afference with a significantly increased frequency power band 0,00-0.05 Hz in anterior / posterior (A / P) and medio / lateral directions (M / L) (EO M / L: F 2.43 = 8.01; p = 0.001; EO A / P: F 2.43 = 6.73; p = 0.003; EC M / L: F 2.43 = 11.09; p = 0.000; EC A / P: F 2.43 = 5.73; p = 0.006). CONCLUSION Our study has confirmed an increased sway area indicating increased postural instability in patients with PSP compared to patients with IPS and age-matched controls. In addition, the low frequency power (< 1 Hz) in A / P and M / L directions corresponds with disturbances of the visual system. To the best of our knowledge, this is the first study to show that visual disturbances detected by fast-Fourier analysis from posturography may serve as a potential diagnostic marker to help clinicians differentiate between IPS and PSP.