Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson's disease.
Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson's disease.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Nijmegen, NL · Author affiliation
Center of Expertise for Parkinson and Movement Disorders, Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.Location evidence
London, GB · Author affiliation
Center for Preventive Neurology Wolfson Institute of Population Health, Queen Mary University of London, London, UK.Location evidence
Boston, US · Author affiliation
Department of Nutrition and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Location evidence
Palo Alto, US · Author affiliation
23andMe Research Institute, Palo Alto, CA, USA.Location evidence
Davis, US · Author affiliation
Davis Phinney Foundation, Louisville, CO, USA.Location evidence
Bristol, GB · Author affiliation
Population Health Sciences, Bristol Medical School, Bristol, UK.Location evidence
Rotterdam, NL · Author affiliation
Department of Public Health, Medical Ethics, Philosophy and History of Medicine Programme, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.Location evidence
Newcastle upon Tyne, GB · Author affiliation
Translational and Clinical Research Institute, Newcastle University National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Newcastle University, Newcastle upon Tyne, UK.Location evidence
Pittsburgh, US · Author affiliation
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.Location evidence
Chicago, US · Author affiliation
Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.Location evidence
Heemstede, NL · Author affiliation
Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands.Location evidence
Amsterdam, NL · Author affiliation
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam, The Netherlands.Location evidence
US · Author affiliation · country only
Department of Neurology and Center for Health and Technology, University of Rochester, Rochester, NY, USA.Location evidence
New York City, US · Author affiliation
Center for the Brain & Environment, Atria Research and Global Health Institute, New York, NY, USA.Location evidence
Paris, FR · Author affiliation
Institut du Cerveau - Paris Brain Institute, Movement Investigations and Therapeutics Team (MOV'IT), Center for NeuroImaging Research (CENIR), Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France.Location evidence
DE · Author affiliation · country only
Institute of Neurogenetics, University of Luebeck and University Hospital Schleswig-Holstein, Luebeck, Germany.Location evidence
Basel, CH · Author affiliation
Roche Pharma Research and Early Development, Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland.Location evidence
Groningen, NL · Author affiliation
Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Location evidence
NL · Author affiliation · country only
Sleep Medicine Center Kempenhaeghe, Heeze, The Netherlands.Location evidence
GB · Author affiliation · country only
Norfolk Smell & Taste Clinic, James Paget University Hospital, Gorleston, Norfolk, UK.Location evidence
Norwich, GB · Author affiliation
Rhinology & Olfactology Research Group, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.Location evidence
Montréal, CA · Author affiliation
The Neuro, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.Location evidence
Bonn, DE · Author affiliation
Center of Neurology, Department of Parkinson's, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany & German Center for Neurodegenerative Diseases, Bonn, Germany.Location evidence
Innsbruck, AT · Author affiliation
Center for Sleep Medicine, Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.Location evidence
Follow the study behind this paper
App-supported activity for people with a dream-sleep movement disorder
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Using an app to encourage more physical activity
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Original abstract
We describe the design of the first non-pharmacological Parkinson's disease prevention trials worldwide: the randomised 'Slow-SPEED' trials. Three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise intervention vs. active control over 18-36 months in complementary prodromal subgroups: iRBD(n = 110; Netherlands), hyposmia(n = 110; United Kingdom) or LRRK2/GBA1 mutation carriers(n = 600; United States). These trials will provide unique insights for large-scale Parkinson's prevention studies. Protocols are registered at ClinicalTrials.gov(NCT06193252[1-5-2024];NCT06600438[9-19-2024];NCT06993142[5-28-2025]).