ガンマナイフによる組織変化と臨床応用
ガンマナイフによる組織変化と臨床応用
A plain-language reading has not been prepared for this paper yet.
Original abstract
application/pdf Gamma knife surgery (GKS) has been increasingly utilized to manage a wide variety of indications including arteriovenous malformations, brain tumors, Parkinson disease, or focal epilepsy. In clinical, practice, GKS is thought to be a safe and effective treatment for these diseases, even if patients are old or at high risk; however, little is understood about the alteration of biological properties induced by gamma irradiation during procedures using this device. In recent studies using animals, it has been shown that low-dose gamma irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells, whereas a high dose causes marked degeneration of the capillary endothelial cells, consequently inducing edema and necrosis in the irradiated area. More recently, GKS has also been employed to treat intractable pain control, such as trigeminal neuralgia, thalamic pain and cancer pain. Some investigators have suggested that gamma irradiation may relieve completely these pains by increasing the levels of β-en-dorphin in both blood and cerebrospinal fluid. Thus, it is very important to conduct further basic experiments to determine the optimal treatment protocol using GKS for various diseases across many fields.