[Contribution to a discussion on the importance of the non-tricyclic antidepressives for the development of a theory of depression (author's transl)].
[Contribution to a discussion on the importance of the non-tricyclic antidepressives for the development of a theory of depression (author's transl)].
A plain-language reading has not been prepared for this paper yet.
Original abstract
Clinical and experimental research on antidepressive drugs during the 10 years which elapsed since Kuhn's first paper in 1957 centered mainly around the tricyclic compounds. This gave considerable support to the noradrenaline hypothesis of depression, although it did not furnish any definite proof. Since 1968, reports have been published on the antidepressive action of non-tricyclic compounds, stimulating the exploration of new theoretical avenues. The article discusses briefly the theoretical prerequisite of "emotional integration" as an important factor in depression and of the "double receptors" for parkinsonism, using the development of trazodone as an example.