Epidemiology and clinical features of movement disorders in a Mexican Mestizo cohort: a 10-year tertiary-center study.
Epidemiology and clinical features of movement disorders in a Mexican Mestizo cohort: a 10-year tertiary-center study.
Where did the research take place?
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Guadalajara, MX · Possible study site
METHODS: We conducted a 10-year retrospective cohort study (2012-2022) analyzing medical records from the Movement Disorders and Neurodegenerative Diseases Unit at the Hospital Civil de Guadalajara, a public tertiary university hospital from the western region of Mexico.Location evidence
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Original abstract
BACKGROUND: Movement disorders comprise a heterogeneous spectrum of neurological conditions characterized by impaired motor control. Limited epidemiological data exist for Latin American populations, particularly for Mexican Mestizos. OBJECTIVE: To characterize the epidemiological profile and clinical features of movement disorders in a large cohort of Mexican Mestizo patients evaluated at a public tertiary referral center in western Mexico. METHODS: We conducted a 10-year retrospective cohort study (2012-2022) analyzing medical records from the Movement Disorders and Neurodegenerative Diseases Unit at the Hospital Civil de Guadalajara, a public tertiary university hospital from the western region of Mexico. Inclusion criteria were confirmed movement disorder diagnosis and a minimum of two clinical evaluations. Binary logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CIs). RESULTS: Among 1,830 records (mean age 58.5 ± 17.0 years, 53.9% female, all self-identified as Mexican Mestizo), hypokinetic disorders comprised 63.9% (n = 1,170) and hyperkinetic disorders 36.1% (n = 660). Parkinsonism (63.6%, n = 1,163) and tremor (11.3%, n = 206) were the most frequent subtypes. Hypokinetic disorders were associated with older age (64.2 ± 12.8 vs. 48.5 ± 18.9 years, p < 0.001), hypertension (OR = 2.29; 1.78-2.95; p = 0.001), and smoking (OR = 1.51; 1.13-2.03; p = 0.005). Hyperkinetic disorders were associated with male sex (OR = 1.47; 1.19-1.82; p < 0.001), family history (OR = 1.92; 1.49-2.47; p < 0.001), and functional presentations (OR = 11.0; 5.53-22.14; p < 0.001). CONCLUSION: This is the largest reported Mexican Mestizo cohort with movement disorders evaluated in a single public tertiary center. Findings reveal distinct demographic and clinical patterns and may inform integrated cardiovascular-neurological care models, screening protocols, and resource allocation within the Mexican public health system.