Theta-frequency subthalamic nucleus deep brain stimulation selectively improves visual attention in Parkinson's disease.
Theta-frequency subthalamic nucleus deep brain stimulation selectively improves visual attention in Parkinson's disease.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Beijing, CN · Author affiliation
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Location evidence
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Original abstract
OBJECTIVE: Visual attention deficits are common but under-recognized in Parkinson's disease (PD), and we investigate whether theta-frequency (5 Hz) STN-DBS differentially modulates visual attention compared with high-frequency (130 Hz) stimulation in PD patients. METHODS: Thirty-nine PD patients with bilateral STN-DBS perform an attentional capture task under three stimulation conditions (OFF, low-frequency, high-frequency). Patients are stratified into impaired (n = 21) and normal (n = 18) visual attention groups based on their accuracy in the AC-distractor task during OFF-stimulation, with <90% accuracy defining impairment. Behavioral accuracy and reaction time are analyzed using Bayesian mixed-effects models. P300 amplitudes and latencies are measured using electroencephalography. RESULTS: In the impaired group, 5 Hz stimulation significantly improves accuracy in the distractor condition compared with OFF (BF > 1,000), whereas 130 Hz stimulation reduces accuracy (BF = 122.8). This behavioral pattern is paralleled by enhanced P300 amplitude and prolonged latency under 5 Hz stimulation, and suppressed P300 amplitude under 130 Hz stimulation. No significant stimulation effects are observed in the normal group. CONCLUSION: Theta-frequency STN-DBS selectively improves visual attention in PD with pre-existing attentional deficits, likely by enhancing top-down attentional resource allocation, while high-frequency stimulation impairs performance.