Acute administration of methylphenidate modulates functional connectivity during irrelevant stimuli processing in Parkinson's disease.
Acute administration of methylphenidate modulates functional connectivity during irrelevant stimuli processing in Parkinson's disease.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Chengdu, CN · Author affiliation
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.Location evidence
Alcorcón, ES · Author affiliation
Department of Neurology, Hospital Universitario Fundación Alcorcon, Alcorcon, Spain.Location evidence
IL · Author affiliation · country only
Neurological Institute, Sourasky Medical Center; Tel-Aviv University, Israel.Location evidence
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Original abstract
OBJECTIVE: Methylphenidate (MPD) may have therapeutic benefits in Parkinson's disease (PD) patients. However, the effects of MPD on attentional functional connectivity (FC) networks, in PD, have not been investigated to date. Our objective was to examine the effects of a single dose of MPD, on event-related FC, in PD. The study was a randomized, double-blind, placebo-controlled, single-dose, cross-over clinical trial. METHODS: We recorded electroencephalogram (EEG) in PD patients during the performance of an extended version of a visual oddball task. We evaluated FC during the processing of task-relevant (targets, predictive sequence) and task-irrelevant (randomized standards) stimuli, using the weighted phase-locking index and graph theory. Two recording sessions (20 mg MPD or placebo) were performed in each patient. RESULTS: MPD, in comparison with placebo, modulated FC during the processing of standards, within the theta band, in PD patients. MPD induced decreases in the FC and global efficiency within fronto-parietal networks, during the processing of task-irrelevant stimuli. CONCLUSIONS: In PD patients, the administration of a single dose of MPD, compared with placebo, attenuated FC within fronto-parietal networks, during the processing of non-informative standards. SIGNIFICANCE: MPD may have cognitive therapeutic effects in PD, by modulating attention during the processing of task-irrelevant stimuli.