Total synthesis and biological evaluation of catenulobactin B as neuroprotective agent.
Total synthesis and biological evaluation of catenulobactin B as neuroprotective agent.
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Jiangmen, CN · Author affiliation
School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong 529020, China.Location evidence
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Original abstract
The first total synthesis of catenulobactin B has been accomplished in longest linear eight steps (34% overall yield). The convergent route featured a molybdenum(VI) oxide-promoted dehydrative cyclization, a key double amide coupling strategy and a set of judicious functional group transformations. Biological evaluation revealed that catenulobactin B markedly inhibited α-synuclein aggregation and attenuated the progression of 6-OHDA-induced dopaminergic neurodegeneration in C. elegans. This neuroprotective effect may be closely associated with the modulation of iron metabolism-related gene expression. These findings identify catenulobactin B as a promising neuroprotective agent targeting iron homeostasis for Parkinson's disease-related neurodegeneration.