The phenyl carbamates JBPOS0101 and JBPOS0607 attenuate rotenone-induced dopaminergic neuronal death in mice.
The phenyl carbamates JBPOS0101 and JBPOS0607 attenuate rotenone-induced dopaminergic neuronal death in mice.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
KR · Author affiliation · country only
School of Biological Sciences and Technology, College of Natural Sciences, College of Medicine, Institute of Systems Biology & Life Science Informatics, Chonnam National University, Gwangju, Republic of Korea.Location evidence
Suwon, KR · Author affiliation
Bio-Pharm Solutions Co. Ltd, Suwon, Gyeonggi-Do, Republic of Korea.Location evidence
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Original abstract
Parkinson's disease (PD) is a progressive neurodegenerative disease that causes motor abnormalities such as tremors, rigidity, and posture imbalance. The loss of dopaminergic neurons and Lewy bodies containing the aggregation of α-synuclein are the main neuropathological features of PD. Rotenone, a widely used pesticide and mitochondrial complex I inhibitor, induces dopaminergic neuronal death and is used to model PD in rodents. We previously reported that JBPOS0101, a phenyl carbamate compound, attenuates amyloid β accumulation and memory impairment in the 5xFAD mouse model of Alzheimer's disease. In this study, we investigated the effect of JBPOS0101 and its derivative, JBPOS0607, in rotenone-administered mice as a PD model. Both drugs significantly attenuated the loss of dopaminergic neurons induced by rotenone in mice. Furthermore, the rotenone-induced accumulation of phosphorylated α-synuclein in dopaminergic neurons was also attenuated by the drugs. Additionally, both drugs alleviated rotenone-induced activation of astrocytes and microglia compared to the group treated with rotenone alone. These results indicate that the phenyl carbamates JBPOS0101 and JBPOS0607 attenuate rotenone-induced dopaminergic neurodegeneration in mice. Both compounds preserved nigral dopaminergic neurons and attenuated alpha-synuclein phosphorylation, glial activation, and pro-inflammatory cytokine levels in the striatum, and JBPOS0607 was also effective in restoring the anti-inflammatory cytokine IL-10, striatal dopamine levels, and motor performance, supporting the therapeutic potential of phenyl carbamates in Parkinson's disease.