Dysphagia and gastrointestinal disorders in Parkinson's disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team.
Dysphagia and gastrointestinal disorders in Parkinson's disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
DE · Author affiliation · country only
Department of Neurology, University Hospital of Muenster, Albert-Schweitzer- Campus 1, 48149, Muenster, Germany. inga.claus@ukmuenster.de.Location evidence
Hamburg, DE · Author affiliation
Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.Location evidence
Innsbruck, AT · Author affiliation
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.Location evidence
Recklinghausen, DE · Author affiliation
Department of Neurology, Knappschaft Hospital Recklinghausen, Recklinghausen, Germany.Location evidence
Erlangen, DE · Author affiliation
Department of Molecular Neurology, University Hospital Erlangen, Friedrich- Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.Location evidence
Leipzig, DE · Author affiliation
Department of Neurology, University of Leipzig, Leipzig, Germany.Location evidence
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Original abstract
Gastrointestinal Disorders in people with Parkinson's disease (PwP) are able to cause widespread clinical symptoms which can be challenging to classify in day-to-day clinical practice. In the upper gastrointestinal tract (GIT) oropharyngeal dysphagia, esophageal motility disorders as well as delayed gastric emptying may cause nutrition problems and reduce the efficacy of oral pharmacotherapy. In the lower GIT, bacterial overgrowth and prolonged colorectal transit times induce different stages of constipation leading to reduced quality of life and GIT comorbidities as well. Most of these symptoms reflect alpha-synuclein pathology in both the enteric nervous system and at various sites of the peripheral and central nervous systems. Besides, the growing use of various device aided therapies may additionally raise specific clinical questions about the interference with the GIT motility. This standard operating procedure (SOP) is intended to provide specific recommendations for diagnostic steps as well as therapeutic options, especially for interprofessional neurological outpatient care teams.