Potential Relevance of Amazonian Diet Components in Parkinson's Disease: An Integrative Review with Multivariate Analysis.
Potential Relevance of Amazonian Diet Components in Parkinson's Disease: An Integrative Review with Multivariate Analysis.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Serra, BR · Author affiliation
Centro Universitário da Serra Gaúcha (FSG), Caxias do Sul 95020-371, RS, Brazil.Location evidence
Caxias do Sul, BR · Author affiliation
Centro Universitário da Serra Gaúcha (FSG), Caxias do Sul 95020-371, RS, Brazil.Location evidence
Manaus, BR · Author affiliation
Centro de Ensino, Pesquisa e Desenvolvimento Tecnológico GERONTEC, Fundação Universidade Aberta da Terceira Idade, FUnATI, Manaus 69029-040, AM, Brazil.Location evidence
BR · Author affiliation · country only
Programa de Pós-Graduação em Gerontologia, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil.Location evidence
São Paulo, BR · Author affiliation
Programa de Pós-Graduação em Ciências do Envelhecimento, Universidade São Judas Tadeu, São Paulo 03166-000, SP, Brazil.Location evidence
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Original abstract
Dietary patterns increasingly influence research on neurodegenerative diseases, with attention shifting from isolated nutrients to integrative nutritional models. The Amazonian Diet, a biodiversity-based dietary pattern rich in native fruits, seeds, freshwater fish, and cassava-derived foods, is naturally enriched in bioactive compounds including polyphenols, anthocyanins, carotenoids, methylxanthines, selenium, vitamins, and unsaturated fatty acids. This review aimed to investigate the potential relevance of key foods derived from the Amazonian Diet to Parkinson's disease (PD) by integrating compositional nutritional analysis, multivariate analytical approaches, and mechanistic evidence synthesis. In Stage 1, the composition of 36 Amazonian foods was analyzed using TBCA and FAO data, followed by hierarchical clustering analysis (Ward's linkage, Euclidean distance). Distinct compositional patterns were identified, highlighting foods with high bioactive diversity, relevant lipid composition, and dietary fiber. In Stage 2, an integrative literature review (PubMed/MEDLINE, SciELO) of in vitro, in vivo, observational, and clinical studies suggested that açaí berry, guaraná, cocoa/cacao, camu-camu, and Brazil nuts contain nutrients and bioactive compounds that intersect with biological pathways implicated in PD, including oxidative stress, mitochondrial dysfunction, and neuroinflammation. However, this review does not evaluate the effects of the Amazonian Diet on PD incidence, progression, symptoms, levodopa response, or biomarkers.