Depression and Mood Changes in People with Parkinson's Disease over Time: A 5-Year Follow-Up Study.
Depression and Mood Changes in People with Parkinson's Disease over Time: A 5-Year Follow-Up Study.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
A Coruña, ES · Author affiliation
Grupo de Investigación en Enfermedad de Parkinson y otros Trastornos del Movimiento, Instituto de Investigación Biomédica de A Coruña (INIBIC), 15006 A Coruña, Spain.Location evidence
Madrid, ES · Author affiliation
Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.Location evidence
Ferrol, ES · Author affiliation
Complejo Hospitalario Universitario de Ferrol (CHUF), 15405 Ferrol, Spain.Location evidence
Sevilla, ES · Author affiliation
Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.Location evidence
Universidad, ES · Author affiliation
Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.Location evidence
Terrassa, ES · Author affiliation
Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain.Location evidence
Centro, ES · Author affiliation
Centro Neurológico Oms 42, 07003, Palma de Mallorca, Spain.Location evidence
Palma, ES · Author affiliation
Centro Neurológico Oms 42, 07003, Palma de Mallorca, Spain.Location evidence
Sant Joan Despí, ES · Author affiliation
Complex Hospitalari Universitari Moisés Broggi, 08970 Sant Joan Despí, Spain.Location evidence
Barcelona, ES · Author affiliation
Hospital Universitario Vall d'Hebron, 08035 Barcelona, Spain.Location evidence
L'Hospitalet de Llobregat, ES · Author affiliation
Consorci Sanitari Integral, Hospital General de L'Hospitalet, 08906 L'Hospitalet de Llobregat, Spain.Location evidence
Santander, ES · Author affiliation
Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain.Location evidence
Elche, ES · Author affiliation
Hospital General Universitario de Elche, 03203 Elche, Spain.Location evidence
Pontevedra, ES · Author affiliation
Complejo Hospitalario Universitario de Pontevedra (CHOP), 36161 Pontevedra, Spain.Location evidence
Móstoles, ES · Author affiliation
Hospital Universitario de Móstoles, 28935 Madrid, Spain.Location evidence
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Original abstract
Background and Objective: Depression is frequent in Parkinson's disease (PD), but it is unclear how mood changes and impacts patient's quality of life (QoL) over time. Our objective was to analyze the frequency of depression and mood changes in people with PD (PwP) over 5 years of follow-up, comparing it with a control group, as well as its relationship with the patients' QoL. Patients and Methods: PwP and healthy controls (HC) recruited from the COPPADIS cohort from January/2016 to November/2017 were included in this 5-year follow-up study. Mood was assessed by the Beck Depression Inventory II (BDI-II), and participants were classified as having major depression, minor depression, subthreshold depression, or non-depression at baseline and at 2, 4, and 5 years of follow-up. Correlation analysis and linear regression models were applied. Results: The BDI-II total score increased from 8.1 ± 6.2 at baseline to 10.3 ± 8.1 at the 5-year follow-up visit in PwP (p < 0.0001) but not in HC (from 4.1 ± 5.2 to 4.0 ± 5.7 [p = 0.896]). The prevalence of depression remained around 50-54% in the PwP group and 21-25% in the HC group throughout the follow-up period, but the mood state showed variability for each patient between visits. Patients' QoL was associated with the depressive state throughout the entire follow-up period (p < 0.0001). Worsening QoL, sleep, longer disease duration, and an increase in neuropsychiatric symptoms were identified as independent factors associated with a worsening of mood over time in PwP (N = 348). Conclusions: Mood change over time in PwP is associated with QoL.